ORBi: Detry Benoît - Digging deeper into lymphatic vessel formation in vitro and in vivo

Reference : Digging deeper into lymphatic vessel formation in vitro and in vivo


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/105032

Title :	Digging deeper into lymphatic vessel formation in vitro and in vivo
Language :	English
Author, co-author :	Detry, Benoît [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
	Bruyère, F. [ > > ]
	Erpicum, Charlotte [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
	Paupert, Jenny [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Lamaye, Françoise [ > > ]
	Maillard, Catherine [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Lenoir, Bénédicte [ > > ]
	Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
	Thiry, Marc [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
	Noël, Agnès [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Publication date :	24-Jun-2011
Journal title :	BMC Cell Biology
Publisher :	BioMed Central
Volume :	12
Pages :	29
Audience :	International
e-ISSN :	1471-2121
Abstract :	[en] Background Abnormal lymphatic vessel formation (lymphangiogenesis) is associated with different pathologies such as cancer, lymphedema, psoriasis and graft rejection. Lymphatic vasculature displays distinctive features than blood vasculature, and mechanisms underlying the formation of new lymphatic vessels during physiological and pathological processes are still poorly documented. Most studies on lymphatic vessel formation are focused on organism development rather than lymphangiogenic events occurring in adults. We have here studied lymphatic vessel formation in two in vivo models of pathological lymphangiogenesis (corneal assay and lymphangioma). These data have been confronted to those generated in the recently set up in vitro model of lymphatic ring assay. Ultrastructural analyses through Transmission Electron Microscopy (TEM) were performed to investigate tube morphogenesis, an important differentiating process observed during endothelial cell organization into capillary structures.
Permalink :	http://hdl.handle.net/2268/105032
DOI :	10.1186/1471-2121-12-29
Framework Programme / European Project :	FP7 ; 201279 - MICROENVIMET - Understanding and fighting metastasis by modulating the tumour microenvironment through interference with the protease network.

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Open access	Detry BMC 2011.pdf		Publisher postprint	8.14 MB	View/Open

All documents in ORBi are protected by a user license.

Dspace v1.5