Reference : Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the repli...
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/104323
Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program
English
Boxus, Mathieu mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Twizere, Jean-Claude mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Legros, Sébastien [ > > ]
Kettmann, Richard mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Willems, Luc mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
5-Jan-2012
Blood
American Society of Hematology
119
151-160
Yes (verified by ORBi)
International
0006-4971
1528-0020
Washington
DC
[en] The Tax oncoprotein encoded by the Human T-cell leukemia virus type 1 (HTLV-1)
plays a pivotal role in viral persistence and pathogenesis. HTLV-1 infected cells proliferate
faster than normal lymphocytes, expand through mitotic division and accumulate genomic
lesions. Here, we show that Tax associates with the minichromosome maintenance MCM2-7
helicase complex and localizes to origins of replication. Tax modulates the spatiotemporal
program of origin activation and fires supplementary origins at the onset of S phase. Thereby,
Tax increases the DNA replication rate, accelerates S phase progression but also generates a
replicative stress characterized by the presence of genomic lesions. Mechanistically, Tax
favors p300 recruitment and histone hyperacetylation at late replication domains advancing
their replication timing in early S phase.
http://hdl.handle.net/2268/104323
10.1182/blood-2011-05-356790

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