ORBi: Boxus Mathieu - Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program

Reference : Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the repli...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Oncology
	To cite this reference:	http://hdl.handle.net/2268/104323

Title :	Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program
Language :	English
Author, co-author :	Boxus, Mathieu [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
	Twizere, Jean-Claude [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
	Legros, Sébastien [ > > ]
	Kettmann, Richard [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
	Willems, Luc [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Publication date :	5-Jan-2012
Journal title :	Blood
Publisher :	American Society of Hematology
Volume :	119
Pages :	151-160
Audience :	International
ISSN :	0006-4971
e-ISSN :	1528-0020
City :	Washington
Country :	DC
Abstract :	[en] The Tax oncoprotein encoded by the Human T-cell leukemia virus type 1 (HTLV-1) plays a pivotal role in viral persistence and pathogenesis. HTLV-1 infected cells proliferate faster than normal lymphocytes, expand through mitotic division and accumulate genomic lesions. Here, we show that Tax associates with the minichromosome maintenance MCM2-7 helicase complex and localizes to origins of replication. Tax modulates the spatiotemporal program of origin activation and fires supplementary origins at the onset of S phase. Thereby, Tax increases the DNA replication rate, accelerates S phase progression but also generates a replicative stress characterized by the presence of genomic lesions. Mechanistically, Tax favors p300 recruitment and histone hyperacetylation at late replication domains advancing their replication timing in early S phase.
Permalink :	http://hdl.handle.net/2268/104323
DOI :	10.1182/blood-2011-05-356790

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