Reference : Safety of long-term treatment of HAM/TSP patients with valproic acid
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/104319
Safety of long-term treatment of HAM/TSP patients with valproic acid
English
Olindo, Stéphane [ > > ]
Belrose, Gildas [ > > ]
Gillet, Nicolas mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Rodriguez, Sabrina mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Boxus, Mathieu mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Verlaeten, Olivier [ > > ]
Asquith, Becca [ > > ]
Bangham, Charles [ > > ]
Signaté, Aïssatou [ > > ]
Smadja, Didier [ > > ]
Lezin, Agnès [ > > ]
Césaire, Raymond [ > > ]
Willems, Luc mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
8-Dec-2011
Blood
American Society of Hematology
118
24
6306-6309
Yes (verified by ORBi)
International
0006-4971
1528-0020
Washington
DC
[en] HTLV-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a neurodegenerative disease of the central nervous system induced by Human T lymphotropic virus type 1 (HTLV-1). As a potential therapeutic approach, we previously suggested reducing the proviral load (PVL) by modulating lysine deacetylase activity using valproic acid (VPA) and exposing virus-positive cells to the host immune response. We conducted a single-center, two-year open-label trial, with 19 HAM/TSP volunteers treated with oral VPA. PVL, CD38/HLA-DR expression and CD8+ lysis efficiency were not significantly affected by VPA. Mean scores of HAM/TSP disability did not differ between baseline and final visit. Walking Time Test (WTT) increased significantly (>20%) in 3 patients and was in keeping with minor VPA side effects (drowsiness and tremor). WTT improved rapidly after VPA discontinuation. We conclude that long term treatment with VPA is safe in HAM/TSP.
Researchers
http://hdl.handle.net/2268/104319
10.1182/blood-2011-04-349910

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