Reference : Viral expression directs the fate of B cells in BLV-infected sheep.
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/104316
Viral expression directs the fate of B cells in BLV-infected sheep.
English
Florins, Arnaud-Francois [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
De Brogniez, Alix [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Elemans, M. [> >]
Bouzar, A.-B. [> >]
François, C. [> >]
Reichert, M. [> >]
Asquith, B. [> >]
Willems, Luc mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Jan-2012
Journal of Virology
American Society for Microbiology (ASM)
86
1
621-624
Yes (verified by ORBi)
International
0022-538X
1098-5514
Washington
DC
[en] The host immune response is believed to tightly control viral replication of deltaretroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV). However, this assumption has not been definitely proven in vivo. In order to further evaluate the importance of immune response in the BLV model, we studied the fate of cells in which viral expression was transiently induced. Using a dual fluorochrome labeling approach, we show that ex vivo induction of viral expression induces higher death rates of B cells in vivo. Furthermore, cyclosporine treatment of these animals indicated that an efficient immune response is required to control virus expressing cells.
http://hdl.handle.net/2268/104316
10.1128/JVI.05718-11

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