Reference : Reduction of B cell turnover in chronic lymphocytic leukaemia.
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/10429
Reduction of B cell turnover in chronic lymphocytic leukaemia.
English
Defoiche, Julien [> > > >]
Debacq, Christophe [> > > >]
Asquith, Becca [> > > >]
Zhang, Yan [> > > >]
Burny, Arsene [> > > >]
Bron, Dominique [> > > >]
Lagneaux, Laurence [> > > >]
Macallan, Derek [> > > >]
Willems, Luc mailto [Université de Liège - ULg > > GIGA-Research >]
2008
British Journal of Haematology
Blackwell Publishing
143
2
240-7
Yes (verified by ORBi)
International
0007-1048
1365-2141
Oxford
United Kingdom
[en] Adult ; Aged ; B-Lymphocytes/metabolism/pathology ; Case-Control Studies ; Cell Proliferation ; DNA/metabolism ; Deoxyadenosines/analysis/metabolism ; Deuterium/analysis/diagnostic use/metabolism ; Female ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Male ; Middle Aged
[en] Whether chronic lymphocytic leukaemia (CLL) is a latent or a proliferating disease has been intensively debated. Whilst the dogma that CLL results from accumulation of dormant lymphocytes is supported by the unresponsiveness of leukaemic cells to antigens and polyclonal activators, recent in vivo kinetic measurements indicate that B lymphocytes do divide at significant rates in CLL. However, an important and still unanswered question is whether CLL cells proliferate faster or slower compared with their normal counterparts. This report addressed directly this point and compared B-cell kinetics in CLL subjects and healthy controls, using a pulse-chase approach based on incorporation of deuterium from 6,6-(2)H(2)-glucose into DNA. We confirmed that B cells proliferated at significant levels in CLL but found that the proliferation rates were reduced compared with healthy subjects (mean 0.47 vs. 1.31%/d respectively, P = 0.007), equivalent to an extended doubling time of circulating B cells (147 d vs. 53 d). In conclusion, CLL B cells proliferate at reduced levels compared with healthy controls. CLL is thus characterized by an aberrant B-cell kinetics with a decrease in cell turnover, an observation that may impact on elaboration of efficient therapeutic strategies.
http://hdl.handle.net/2268/10429
10.1111/j.1365-2141.2008.07348.x

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