Article (Scientific journals)
The HTLV-1 Tax interactome.
Boxus, Mathieu; Twizere, Jean-Claude; Legros, Sebastien et al.
2008In Retrovirology, 5, p. 76
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Keywords :
Cell Cycle Proteins/genetics/metabolism; Gene Products, tax/chemistry/genetics/metabolism; HTLV-I Infections/metabolism/physiopathology/virology; Host-Pathogen Interactions; Human T-lymphotropic virus 1/chemistry/enzymology/genetics; Humans; Nuclear Pore Complex Proteins/genetics/metabolism; Protein Binding; Protein Structure, Tertiary; Signal Transduction; Transcription Factors/genetics/metabolism; Transcriptional Activation
Abstract :
[en] The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.
Disciplines :
Oncology
Author, co-author :
Boxus, Mathieu ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Twizere, Jean-Claude  ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Legros, Sebastien
Dewulf, Jean-François
Kettmann, Richard ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Willems, Luc  ;  Université de Liège - ULiège > GIGA-Research
Language :
English
Title :
The HTLV-1 Tax interactome.
Publication date :
2008
Journal title :
Retrovirology
eISSN :
1742-4690
Publisher :
BioMed Central, London, United Kingdom
Volume :
5
Pages :
76
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 April 2009

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