Reference : Emphasis on cell turnover in two hosts infected by bovine leukemia virus: a rationale fo...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/10427
Emphasis on cell turnover in two hosts infected by bovine leukemia virus: a rationale for host susceptibility to disease.
English
Florins, Arnaud-Francois [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Boxus, Mathieu mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Vandermeers, Fabian [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Verlaeten, Olivier [> > > >]
Bouzar, Amel [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Defoiche, Julien [> > > >]
Hubaux, Roland [> >]
Burny, Arsene [> > > >]
Kettmann, Richard mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Willems, Luc mailto [Université de Liège - ULg > > GIGA-Research >]
2008
Veterinary Immunology and Immunopathology
Elsevier Science
125
1-2
1-7
Yes (verified by ORBi)
International
0165-2427
Amsterdam
The Netherlands
[en] Animals ; B-Lymphocytes/immunology/pathology ; Cattle ; Enzootic Bovine Leukosis/genetics/immunology/pathology/virology ; Genes, p53 ; Leukemia Virus, Bovine/immunology ; Lymphocyte Activation ; Lymphoid Tissue/immunology/pathology ; Sheep ; Sheep Diseases/genetics/immunology/pathology/virology
[en] Bovine leukemia virus (BLV) is a deltaretrovirus that infects and induces accumulation of B-lymphocytes in the peripheral blood and lymphoid tissues of cattle, leading to leukemia/lymphoma. BLV can also be experimentally transmitted to sheep, in which disease appears earlier and at higher frequencies. Abnormal accumulation of leukemic B-lymphocytes results from an alteration of different parameters that include cell proliferation and death as well as migration to lymphoid tissues. Interestingly, B lymphocyte turnover is increased in BLV-infected sheep but reduced in cattle, revealing a potential relationship between cell kinetics and disease progression.
http://hdl.handle.net/2268/10427
10.1016/j.vetimm.2008.04.007

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