Reference : Sirtuin 1 Promotes Th2 Responses and Airway Allergy by Repressing Peroxisome Proliferato...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/104233
Sirtuin 1 Promotes Th2 Responses and Airway Allergy by Repressing Peroxisome Proliferator-Activated Receptor-γ Activity in Dendritic Cells
English
Legutko, Agnieszka* [Université de Liège - ULg > Laboratory of Cellular and Molecular Physiology, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-Research) > > >]
Marichal, Thomas* mailto [Université de Liège - ULg > Laboratory of Cellular and Molecular Physiology, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-Research) > > >]
Fievez, Laurence mailto [Université de Liège - ULg > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire >]
Bedoret, Denis [Université de Liège - ULg > Laboratory of Cellular and Molecular Physiology, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-Research) > > > >]
Mayer, Alice [Université de Liège - ULg > Faculty of Veterinary Medicine > > >]
de Vries, Hilda [Université Libre de Bruxelles - ULB > Laboratory of Animal Physiology, Institute of Molecular Biology and Medicine > > >]
Klotz, Luisa [The Netherlands Cancer Institute, Amsterdam, The Netherlands > > > >]
Drion, Pierre mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim. >]
Heirman, Carlo [Université de Liège - ULg > Animal Facility, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-Research) > > >]
CATALDO, Didier mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
LOUIS, Renaud mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
Thielemans, Kris [> >]
Andris, Fabienne [Université Libre de Bruxelles - ULB > Department of Physiology and Immunology > > >]
Leo, Oberdan [> >]
Lekeux, Pierre mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie >]
Desmet, Christophe mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie >]
Bureau, Fabrice mailto [Université de Liège - ULg > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire >]
* These authors have contributed equally to this work.
2011
Journal of Immunology
American Association of Immunologists
187
9
4517-4529
Yes (verified by ORBi)
International
0022-1767
1550-6606
Baltimore
MD
[en] Sirtuins are a unique class of NAD+-dependent deacetylases that regulate diverse biological functions such as aging, metabolism, and stress resistance. Recently, it has been shown that sirtuins may have anti-inflammatory activities by inhibiting proinflammatory transcription factors such as NF-κB. In contrast, we report in this study that pharmacological inhibition of sirtuins dampens adaptive Th2 responses and subsequent allergic inflammation by interfering with lung dendritic cell (DC) function in a mouse model of airway allergy. Using genetic engineering, we demonstrate that sirtuin 1 represses the activity of the nuclear receptor peroxisome proliferator-activated receptor-γ in DCs, thereby favoring their maturation toward a pro-Th2 phenotype. This study reveals a previously unappreciated function of sirtuin 1 in the regulation of DC function and Th2 responses, thus shedding new light on our current knowledge on the regulation of inflammatory processes by sirtuins.
Researchers ; Professionals
http://hdl.handle.net/2268/104233
10.4049/jimmunol.1101493

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