Reference : Sirtuin 1 Promotes Th2 Responses and Airway Allergy by Repressing Peroxisome Proliferato...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/104233
Sirtuin 1 Promotes Th2 Responses and Airway Allergy by Repressing Peroxisome Proliferator-Activated Receptor-γ Activity in Dendritic Cells
English
Legutko, Agnieszka[Université de Liège - ULg > Laboratory of Cellular and Molecular Physiology, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-Research) > > >]
Marichal, Thomas[Université de Liège - ULg > Laboratory of Cellular and Molecular Physiology, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-Research) > > >]
Fievez, Laurence[Université de Liège - ULg > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire >]
Bedoret, Denis[Université de Liège - ULg > Laboratory of Cellular and Molecular Physiology, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-Research) > > > >]
Mayer, Alice[Université de Liège - ULg > Faculty of Veterinary Medicine > > >]
de Vries, Hilda[Université Libre de Bruxelles - ULB > Laboratory of Animal Physiology, Institute of Molecular Biology and Medicine > > >]
Klotz, Luisa[The Netherlands Cancer Institute, Amsterdam, The Netherlands > > > >]
Drion, Pierre[Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim. >]
Heirman, Carlo[Université de Liège - ULg > Animal Facility, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-Research) > > >]
[en] Sirtuins are a unique class of NAD+-dependent deacetylases that regulate diverse biological functions such as aging, metabolism, and stress resistance. Recently, it has been shown that sirtuins may have anti-inflammatory activities by inhibiting proinflammatory transcription factors such as NF-κB. In contrast, we report in this study that pharmacological inhibition of sirtuins dampens adaptive Th2 responses and subsequent allergic inflammation by interfering with lung dendritic cell (DC) function in a mouse model of airway allergy. Using genetic engineering, we demonstrate that sirtuin 1 represses the activity of the nuclear receptor peroxisome proliferator-activated receptor-γ in DCs, thereby favoring their maturation toward a pro-Th2 phenotype. This study reveals a previously unappreciated function of sirtuin 1 in the regulation of DC function and Th2 responses, thus shedding new light on our current knowledge on the regulation of inflammatory processes by sirtuins.
[Université de Liège - ULg > Laboratory of Cellular and Molecular Physiology, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-Research) > > >]
