Article (Scientific journals)
Sirtuin 1 Promotes Th2 Responses and Airway Allergy by Repressing Peroxisome Proliferator-Activated Receptor-γ Activity in Dendritic Cells
Legutko, Agnieszka; Marichal, Thomas; Fievez, Laurence et al.
2011In Journal of Immunology, 187 (9), p. 4517-4529
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Abstract :
[en] Sirtuins are a unique class of NAD+-dependent deacetylases that regulate diverse biological functions such as aging, metabolism, and stress resistance. Recently, it has been shown that sirtuins may have anti-inflammatory activities by inhibiting proinflammatory transcription factors such as NF-κB. In contrast, we report in this study that pharmacological inhibition of sirtuins dampens adaptive Th2 responses and subsequent allergic inflammation by interfering with lung dendritic cell (DC) function in a mouse model of airway allergy. Using genetic engineering, we demonstrate that sirtuin 1 represses the activity of the nuclear receptor peroxisome proliferator-activated receptor-γ in DCs, thereby favoring their maturation toward a pro-Th2 phenotype. This study reveals a previously unappreciated function of sirtuin 1 in the regulation of DC function and Th2 responses, thus shedding new light on our current knowledge on the regulation of inflammatory processes by sirtuins.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Legutko, Agnieszka ;  Université de Liège - ULiège > Laboratory of Cellular and Molecular Physiology, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-Research)
Marichal, Thomas   ;  Université de Liège - ULiège > Laboratory of Cellular and Molecular Physiology, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-Research)
Fievez, Laurence ;  Université de Liège - ULiège > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire
Bedoret, Denis;  Université de Liège - ULiège > Laboratory of Cellular and Molecular Physiology, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-Research)
Mayer, Alice;  Université de Liège - ULiège > Faculty of Veterinary Medicine
de Vries, Hilda;  Université Libre de Bruxelles - ULB > Laboratory of Animal Physiology, Institute of Molecular Biology and Medicine
Klotz, Luisa;  The Netherlands Cancer Institute, Amsterdam, The Netherlands
Drion, Pierre ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim.
Heirman, Carlo;  Université de Liège - ULiège > Animal Facility, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-Research)
CATALDO, Didier  ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
LOUIS, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Thielemans, Kris
Andris, Fabienne;  Université Libre de Bruxelles - ULB > Department of Physiology and Immunology
Leo, Oberdan
Lekeux, Pierre ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie
Desmet, Christophe   ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie
Bureau, Fabrice  ;  Université de Liège - ULiège > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire
More authors (7 more) Less
 These authors have contributed equally to this work.
Language :
English
Title :
Sirtuin 1 Promotes Th2 Responses and Airway Allergy by Repressing Peroxisome Proliferator-Activated Receptor-γ Activity in Dendritic Cells
Publication date :
2011
Journal title :
Journal of Immunology
ISSN :
0022-1767
eISSN :
1550-6606
Publisher :
American Association of Immunologists, Baltimore, United States - Maryland
Volume :
187
Issue :
9
Pages :
4517-4529
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 November 2011

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