Article (Scientific journals)
Effect of short-term oral and inhaled corticosteroids on airway inflammation and responsiveness in a feline acute asthma model
Leemans, Jérôme; Kirschvink, Nathalie; Clercx, Cécile et al.
2011In Veterinary Journal, p. 41-48
Peer Reviewed verified by ORBi
 

Files


Full Text
Effect of short-term oral and inhaled corticosteroids on airway inflammation.pdf
Publisher postprint (369.91 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] The objective of this study was to investigate whether high-dose inhaled fluticasone propionate (FP), alone or in combination with salmeterol (SAL), is as effective as oral prednisolone in reducing airway inflammation and obstruction in cats with experimentally-induced acute asthma. Six cats sensitised to Ascaris suum (AS) were enrolled in a prospective controlled therapeutic trial and underwent four aerosol challenges, at 1-month intervals with AS allergen. The allergen - stimulated animals received four consecutive days treatment with either oral prednisolone at 1mg/kg twice daily, 500μg of FP inhaled twice daily, or a combination of FP/SAL at 500μg/50μg inhaled twice daily, respectively, according to a randomised cross-over design. Treatment-related changes in lung function, airway responsiveness (AR) and bronchoalveolar lavage fluid (BALF) cytology were assessed. Barometric whole-body plethysmography (BWBP) was used for the assessment of respiratory variables and AR. No significant differences in respiratory rate or Penh (an estimate of airflow limitation measured by BWBP) were detected among treatment groups. Allergen-induced airway hyper-responsiveness was significantly inhibited by all three steroid treatments (P<0.05). The mean BALF eosinophil percentage (±SEM) was lower after oral and inhaled corticosteroid treatment and these changes were significant for groups receiving prednisolone and the FP/SAL combination. Findings suggest high-dose FP, particularly in combination with SAL, is effective in ameliorating airway inflammation and hyper-responsiveness in this model of acute feline asthma, and highlight the potential use of these drugs in cats experiencing acute exacerbations of the naturally occurring disease.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Leemans, Jérôme
Kirschvink, Nathalie
Clercx, Cécile  ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Pathologie médicale des petits animaux
Snaps, Frédéric ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Imagerie médicale
Gustin, Pascal ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie
Language :
English
Title :
Effect of short-term oral and inhaled corticosteroids on airway inflammation and responsiveness in a feline acute asthma model
Publication date :
24 January 2011
Journal title :
Veterinary Journal
ISSN :
1090-0233
eISSN :
1532-2971
Publisher :
Elsevier
Pages :
41-48
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2011 Elsevier Ltd. All rights reserved.
Available on ORBi :
since 28 November 2011

Statistics


Number of views
114 (17 by ULiège)
Number of downloads
10 (1 by ULiège)

Scopus citations®
 
34
Scopus citations®
without self-citations
33
OpenCitations
 
23

Bibliography


Similar publications



Contact ORBi