Reference : Neural network involved in young and elderly adults
Scientific congresses and symposiums : Paper published in a book
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/104169
Neural network involved in young and elderly adults
English
Feyers, Dorothée mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Collette, Fabienne mailto [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Neuropsychologie >]
D'Argembeau, Arnaud mailto [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Psychopathologie cognitive >]
Majerus, Steve mailto [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Psychopathologie cognitive >]
Salmon, Eric mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
11-Apr-2008
Proceedings of the Cognitive Aging Conference
83
Yes
International
2008 Cognitive Aging Conference
du 10 avril 2008 au 13 avril 2008
Atlanta
USA
[en] self-judgment ; Aging ; FMRI
[en] In agreement with the literature, we have recently observed that the ventro-medial prefrontal cortex (VMPFC) is activated both in young and elderly subjects during a adjective judgment task requiring judgment about self vs. other in the context of a first (1PP) or third (3PP) perspective-taking (Ruby et al., submitted). Here, we have performed functional connectivity analyses to determine the network of cerebral areas associated to the performance of young and elderly subjects.
Results indicate that, in the 1PP condition, activity of the VMPFC is related to the medial orbito-frontal, posterior and inferior temporal and parietal areas in elderly, but to the occipital cortex only in young subjects. In the 3PP condition, functional connectivity exist between the VMPFC and posterior temporal and lateral orbito-frontal areas in elderly, but with occipital and parietal areas only in young subjects.
The cerebral areas associated to VMPFC activity in young subjects were previously described as involved both in autobiographic memory retrieval and mentalizing processes. With regard to elderly, the cerebral network evidenced is related to autobiographic memory retrieval (parietal and temporal areas) but also to the attribution of emotional valence to the adjectives (medial orbito-frontal) and perspective taking both in 1PP and 3PP conditions (lateral orbito-frontal).
These results indicate (1) that the VMPFC is connected to a larger cerebral network in elderly than in young subjects during self judgements; (2) that young subjects perform the task on the basis of autobiographical information retrieval only, while elderly subjects use supplementary, more reflexive, cognitive processes.
http://hdl.handle.net/2268/104169

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