ORBi: Grulke Sigrid - Plasma myeloperoxidase level and polymorphonuclear leukocyte activation in horses suffering from large intestinal obstruction requiring surgery: preliminary results.

Reference : Plasma myeloperoxidase level and polymorphonuclear leukocyte activation in horses suffer...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Veterinary medicine & animal health
	To cite this reference:	http://hdl.handle.net/2268/10413

Title :	Plasma myeloperoxidase level and polymorphonuclear leukocyte activation in horses suffering from large intestinal obstruction requiring surgery: preliminary results.
Language :	English
Author, co-author :	Grulke, Sigrid [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés >]
	Benbarek, H. [> > > >]
	Caudron, I. [> > > >]
	Deby, Ginette [Université de Liège - ULg > > Centre de l'oxygène : Recherche et développement (C.O.R.D.) >]
	Mathy, Marianne [Université de Liège - ULg > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.) >]
	Farnir, Frédéric [Université de Liège - ULg > Département de productions animales > Biostatistique, économie, sélection animale >]
	Deby, Christiane [Centre Hospitalier Universitaire de Liège - CHU > > Service administration des patients >]
	Lamy, Maurice [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
	Serteyn, Didier [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
Publication date :	1999
Journal title :	Canadian Journal of Veterinary Research = Revue Canadienne de Recherche Vétérinaire
Publisher :	Canadian Veterinary Medical Association
Volume :	63
Issue/season :	2
Pages :	142-7
Audience :	International
ISSN :	0830-9000
City :	Ottawa
Country :	Canada
Keywords :	[en] Acute Disease ; Animals ; Colonic Diseases/physiopathology/surgery/veterinary ; Horse Diseases/blood/physiopathology/surgery ; Horses ; Intensive Care ; Intestinal Obstruction/blood/physiopathology/surgery ; Least-Squares Analysis ; Leukocyte Count ; Neutrophils/physiology ; Peroxidase/blood
Abstract :	[en] Myeloperoxidase (MPO) is a specific enzyme of neutrophil azurophilic granules with a strong oxidative activity. Thanks to a radioimmunoassay of equine myeloperoxidase, the authors have observed a significantly higher plasma level of MPO in horses operated for strangulation obstruction of the large intestine (n = 6) than in horses suffering from a non-strangulating displacement of the large intestine (n = 9). For the 2 groups, 3 phases were distinguished: reception (P1), intensive care (P2) and terminal phase (P3). The mean peak values of MPO for these phases were 121.6 ng/mL (P1), 168.6 ng/mL (P2), and 107.0 ng/mL (P3) for the non-strangulating group, and 242.6 ng/mL (P1); 426.0 ng/mL (P2), and 379.5 ng/mL (P3) for the strangulation group. The variations of the mean peak values of plasma MPO were significantly different between the 2 groups and between the different phases. A significant increase of the least square means of MPO was observed between P1 and P2. A significant decrease of the least square means of the number of circulating leukocytes was observed between P1 and P3. Polymorphonuclear neutrophil activation could play a major role in the pathogenesis of acute abdominal disease and endotoxic shock.
Permalink :	http://hdl.handle.net/2268/10413

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