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Poster (Scientific congresses and symposiums)
SMALL SAMPLE SIZE CAPABILITY INDEX FOR ASSESSING VALIDITY OF ANALYTICAL METHODS
Rozet, Eric; Boulanger, B.; Ziemons, Eric et al.
2012AGROSTAT 2012
 

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Abstract :
[en] Analytical method’s capability evaluation can be a useful methodology to assess the fitness of purpose of these methods for their future routine application. However, care on how to compute the capability indices has to be made. Indeed, the commonly used formulas to compute capability indices such as Cpk, will highly overestimate the true capability of the methods. Especially during methods validation or transfer, there are only few experiments performed and, using in these situations the commonly applied capability indices to declare a method as valid or as transferable to a receiving laboratory will conduct to inadequate decisions. In this work, an improved capability index, namely Cpk-tol and the corresponding estimator of proportion of non conforming results (tolCpk−π) is proposed. Through Monte-Carlo simulations, they have been shown to greatly increase the estimation of analytical methods capability in particular in low sample size situations as encountered during methods validation or transfer. Additionally, the usefulness of this capability index is illustrated through several case studies.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Rozet, Eric ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Boulanger, B.
Ziemons, Eric  ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Marini Djang'Eing'A, Roland ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Hubert, Philippe  ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Language :
English
Title :
SMALL SAMPLE SIZE CAPABILITY INDEX FOR ASSESSING VALIDITY OF ANALYTICAL METHODS
Publication date :
March 2012
Event name :
AGROSTAT 2012
Event place :
Paris, France
Event date :
du 29 février au 2 mars 2012
Audience :
International
Available on ORBi :
since 25 November 2011

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