Reference : Efficacy of monthly oral ibandronate is sustained over 5 years: the MOBILE long-term ...
Scientific journals : Article
Human health sciences : General & internal medicine
http://hdl.handle.net/2268/103721
Efficacy of monthly oral ibandronate is sustained over 5 years: the MOBILE long-term extension study.
English
Miller, P. D. [> > > >]
Recker, R. R. [> > > >]
Reginster, Jean-Yves mailto [Université de Liège - ULg > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé]
Riis, B. J. [> > > >]
Czerwinski, E. [> > > >]
Masanauskaite, D. [> > > >]
Kenwright, A. [> > > >]
Lorenc, R. [> > > >]
Stakkestad, J. A. [> > > >]
Lakatos, P. [> > > >]
2011
Osteoporosis International
Springer Science & Business Media B.V.
Yes (verified by ORBi)
International
0937-941X
1433-2965
Godalming
United Kingdom
[en] The long-term efficacy and safety of once-monthly ibandronate were studied in this extension to the 2-year Monthly Oral Ibandronate in Ladies (MOBILE) trial. Over 5 years, lumbar spine bone mineral density (BMD) increased from baseline with monthly ibandronate 150 mg (8.4%). Long-term monthly ibandronate is effective and well tolerated for up to 5 years in women with postmenopausal osteoporosis. INTRODUCTION: Once-monthly therapy with ibandronate has been studied for up to 5 years in a long-term extension (LTE) to the 2 year MOBILE trial. METHODS: This multicenter, double-blind extension study of monthly ibandronate involved postmenopausal women who had completed 2 years of the MOBILE core study, with >/=75% adherence. Patients were reallocated, or were randomized from daily therapy, to ibandronate 100 mg monthly or 150 mg monthly for a further 3 years. RESULTS: A pooled intent-to-treat (ITT) analysis of 344 patients receiving monthly ibandronate from the core MOBILE baseline showed increases over 5 years in lumbar spine BMD (8.2% with 100 mg and 8.4% with 150 mg). Three-year data relative to MOBILE LTE baseline in the full ITT population of all 698 patients randomized or reallocated from MOBILE (including those previously on daily treatment) showed, on average, maintenance of proximal femur BMD gains achieved in the core 2-year study, with further small gains in lumbar spine BMD. In general, maintenance of efficacy was also indicated by markers of bone metabolism. CONCLUSIONS: There were no tolerability concerns or new safety signals. Monthly treatment with ibandronate 100 and 150 mg is effective and well tolerated for up to 5 years in women with postmenopausal osteoporosis.
http://hdl.handle.net/2268/103721
10.1007/s00198-011-1773-0

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