Reference : Adverse reactions and drug-drug interactions in the management of women with postmeno...
Scientific journals : Article
Human health sciences : General & internal medicine
http://hdl.handle.net/2268/103713
Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis.
English
Rizzoli, Rene [> > > >]
Reginster, Jean-Yves mailto [Université de Liège - ULg > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé]
Boonen, Steven [> > > >]
Breart, Gerard [> > > >]
Diez-Perez, Adolfo [> > > >]
Felsenberg, Dieter [> > > >]
Kaufman, Jean*-Marc [> > > >]
Kanis, John A [> > > >]
Cooper, Cyrus [> > > >]
2011
Calcified Tissue International
Springer Verlag
89
2
91-104
Yes (verified by ORBi)
International
0171-967X
New York
NY
[en] The pharmacological management of disease should involve consideration of the balance between the beneficial effects of treatment on outcome and the probability of adverse effects. The aim of this review is to explore the risk of adverse drug reactions and drug-drug interactions with treatments for postmenopausal osteoporosis. We reviewed evidence for adverse reactions from regulatory documents, randomized controlled trials, pharmacovigilance surveys, and case series. Bisphosphonates are associated with gastrointestinal effects, musculoskeletal pain, and acute-phase reactions, as well as, very rarely, atrial fibrillation, atypical fracture, delayed fracture healing, osteonecrosis of the jaw, hypersensitivity reactions, and renal impairment. Cutaneous effects and osteonecrosis of the jaw are of concern for denosumab (both very rare), though there are no pharmacovigilance data for this agent yet. The selective estrogen receptor modulators are associated with hot flushes, leg cramps, and, very rarely, venous thromboembolism and stroke. Strontium ranelate has been linked to hypersensitivity reactions and venous thromboembolism (both very rare) and teriparatide with headache, nausea, dizziness, and limb pain. The solidity of the evidence base depends on the frequency of the reaction, and causality is not always easy to establish for the very rare adverse reactions. Drug-drug interactions are rare. Osteoporosis treatments are generally safe and well tolerated, though they are associated with a few very rare serious adverse reactions. While these are a cause for concern, the risk should be weighed against the benefits of treatment itself, i.e., the prevention of osteoporotic fracture.
http://hdl.handle.net/2268/103713
10.1007/s00223-011-9499-8

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis.pdfPublisher postprint311 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.