Clinical, bronchoscopic, histopathologic, diagnostic imaging, and arterial oxygenation findings in West Highland White Terriers with idiopathic pulmonary fibrosis.
Heikkilä, H. P.; Lappalaïnen, A. K.; Day, M. J.et al.
2011 • In Journal of Veterinary Internal Medicine, p. 433-439
[en] BACKGROUND:
Idiopathic pulmonary fibrosis (IPF) is a chronic, interstitial lung disease primarily affecting West Highland White Terriers (WHWTs).
OBJECTIVE:
To describe the clinicopathological and diagnostic imaging features in WHWTs with IPF.
ANIMALS:
Twelve WHWTs with IPF and 14 healthy control WHWTs.
METHOD:
Prospective study. Clinical signs and findings of physical examination, blood and arterial blood gas analyses, radiography, high-resolution computed tomography (HRCT), bronchoscopy and bronchoalveolar lavage (BAL) of IPF dogs were obtained and compared with controls. Histopathologic changes in IPF dogs were evaluated.
RESULTS:
Mean partial pressure of oxygen was significantly lower in IPF (mean ± SD, 65.5 ± 15.4 mmHg) than in controls (99.1 ± 7.8 mmHg, P<.001). The alveolar-arterial oxygen gradient was significantly higher in IPF (50.1 ± 17.3 mmHg) than in controls (17.5 ± 4.9 mmHg, P<.001). In HRCT, ground glass opacity (GGO) was detected in all IPF dogs, traction bronchiectasis in 4, and honeycombing in 1. Bronchoscopic airway changes were noted in all IPF dogs. On BAL fluid (BALF) cytology, the total cell count (TCC) was higher in IPF dogs, and the numbers but not the percentages of macrophages, neutrophils, and mast cells were increased. On histopathology, multifocal or diffuse interstitial fibrosis, type II pneumocyte hyperplasia, prominent intraalveolar macrophages, distortion of alveolar architecture, and emphysematous change were detected.
CONCLUSION AND CLINICAL IMPORTANCE:
IPF causes substantial hypoxemia. In HRCT, GGO is a consistent finding. IPF dogs have concurrent airway changes and an increase in BALF TCC.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Heikkilä, H. P.
Lappalaïnen, A. K.
Day, M. J.
Clercx, Cécile ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Pathologie médicale des petits animaux
Rajamäki, M. M.
Language :
English
Title :
Clinical, bronchoscopic, histopathologic, diagnostic imaging, and arterial oxygenation findings in West Highland White Terriers with idiopathic pulmonary fibrosis.
Kottmann RM, Hogan CH, Phipps RP, Sime PJ. Determinants of initiation and progression of idiopathic pulmonary fibrosis. Respirology 2009;14:917-933.
Corcoran BM, Cobb M, Martin MW, et al. Chronic pulmonary disease in West Highland White Terriers. Vet Rec 1999;144:611-616.
Lobetti RG, Milner R, Lane E. Chronic idiopathic pulmonary fibrosis in five dogs. J Am Anim Hosp Assoc 2001;37:119-127.
Norris AJ, Naydan DK, Wilson DW. Interstitial lung disease in West Highland White Terriers. Vet Pathol 2005;42:35-41.
Erikson M, von Euler H, Ekman E, et al. Surfactant protein C in canine pulmonary fibrosis. J Vet Intern Med 2009;23:1170-1174.
Williams K, Malarkey D, Cohn L, et al. Identification of spontaneous feline idiopathic pulmonary fibrosis-morphology and ultrastructural evidence for a type II pneumocyte defect. Chest 2004;125:2278-2288.
American Thoracic Society, European Respiratory Society. Idiopathic pulmonary fibrosis: Diagnosis and treatment. International Consensus Statement. Am J Respir Crit Care Med 2000;161:646-664.
Katzenstein AA, Myers JL. Idiopathic pulmonary fibrosis clinical relevance of pathologic classification. Am J Respir Crit Care Med 1998;157:1301-1315.
Corcoran BM, Dukes-McEwan J, Rhind S, French A. Idiopathic pulmonary fibrosis in a Staffordshire Bull Terrier with hypothyroidism. J Small Anim Pract 1999;40:185-188.
Gotway MB, Freemer MM, King TE Jr. Challenges in pulmonary fibrosis 1: Use of high resolution CT scanning of the lung for the evaluation of patients with idiopathic interstitial pneumonias. Thorax 2007;62:546-553.
Schmidt SL, Sundaram B, Flaherty KR. Diagnosing interstitial lung disease: When is high resolution computed tomography sufficient to make a diagnosis of idiopathic pulmonary fibrosis? Respirology 2009;14:934-939.
Johnson VS, Corcoran BM, Wotton PR, Schwarz T, Sullivan M. Thoracic high-resolution computed tomographic findings in dogs with canine idiopathic pulmonary fibrosis. J Small Anim Pract 2005;46:381-388.
Rajamaki MM, Jarvinen AK, Saari SA, Maisi PS. Effect of repetitive bronchoalveolar lavage on cytologic findings in healthy dogs. Am J Vet Res 2001;62:13-16.
Peeters DE, McKiernan BC, Weisiger RM, Schaeffer DJ, Clercx C. Quantitative bacterial cultures and cytological examination of bronchoalveolar lavage specimens in dogs. J Vet Intern Med 2008;14:534-541.
Kraman SS. Lung sounds for the clinician. Arch Intern Med 1986;146:1411-1412.
Bauer NB, Schneider MA, Neiger R, Moritz A. Liver disease in dogs with tracheal collapse. J Vet Intern Med 2008;20:845-849.
Haskins SC. Interpretation of blood gas measurements. In: King LG, ed. Textbook of Respiratory Disease in Dogs and Cats, 1st ed. St Louis, MO: Saunders Elsevier; 2004:181-193.
Aguilera-Tejero E, Fernandez H, Estepa JC, et al. Arterial blood gases and acid-base balance in geriatric dogs. Res Vet Sci 1997;63:253-256.
Schober KE, Baade H. Doppler echocardiographic prediction of pulmonary hypertension in West Highland White Terriers with chronic pulmonary disease. J Vet Intern Med 2006;20:912-920.
Hunninghake GW, Lynch DA, Galvin JR, et al. Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumonia. Chest 2003;124:1215-1223.
Mercier E, Bolognin M, Hoffmann AC, et al. Influence of age on bronchoscopic findings in healthy Beagle dogs. Vet J 2010; doi: DOI: 10.1016/j.tvjl.2009.12.007.
Woodring JH, Barrett PA, Rehm SR, Nurenberg P. Acquired tracheomegaly in adults as a complication of diffuse pulmonary fibrosis. Am J Roentgenol 1989;152:743-747.
Johnson LR, Pollard RE. Tracheal collapse and bronchomalacia in dogs: 58 cases (7/2001-1/2008). J Vet Intern Med 2009;24:298-305.
Veeraraghavan S, Latsi PI, Wells AU, et al. BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia. Eur Respir J 2003;22:239-244.
American Thoracic Society, European Respiratory Society. International multidisciplinary consensus classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med 2002;165:277-304.
Katzenstein ALA, Mukhopadhyay S, Myers JL. Diagnosis of usual interstitial pneumonia and distinction from other fibrosing interstitial lung diseases. Hum Pathol 2008;39:1275-1294.
