Article (Scientific journals)
Loading and skeletal development and maintenance.
Bergmann, P.; Body, J. J.; BOONEN, S. et al.
2010In Journal of Osteoporosis, 2011, p. 786752
Peer Reviewed verified by ORBi
 

Files


Full Text
Loading and Skeletal Development and Maintenance.pdf
Publisher postprint (1.05 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Mechanical loading is a major regulator of bone mass and geometry. The osteocytes network is considered the main sensor of loads, through the shear stress generated by strain induced fluid flow in the lacuno-canalicular system. Intracellular transduction implies several kinases and phosphorylation of the estrogen receptor. Several extra-cellular mediators, among which NO and prostaglandins are transducing the signal to the effector cells. Disuse results in osteocytes apoptosis and rapid imbalanced bone resorption, leading to severe osteoporosis. Exercising during growth increases peak bone mass, and could be beneficial with regards to osteoporosis later in life, but the gain could be lost if training is abandoned. Exercise programs in adults and seniors have barely significant effects on bone mass and geometry at least at short term. There are few data on a possible additive effect of exercise and drugs in osteoporosis treatment, but disuse could decrease drugs action. Exercise programs proposed for bone health are tedious and compliance is usually low. The most practical advice for patients is to walk a minimum of 30 to 60 minutes per day. Other exercises like swimming or cycling have less effect on bone, but could reduce fracture risk indirectly by maintaining muscle mass and force.
Disciplines :
General & internal medicine
Author, co-author :
Bergmann, P.
Body, J. J.
BOONEN, S.
Boutsen, Y.
Devogelaer, J. P.
Goemaere, S.
Kaufman, J.
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Rozenberg, S.
Language :
English
Title :
Loading and skeletal development and maintenance.
Publication date :
2010
Journal title :
Journal of Osteoporosis
ISSN :
2042-0064
eISSN :
2090-8059
Publisher :
Sage-Hindawi, United States
Volume :
2011
Pages :
786752
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 10 March 2011

Statistics


Number of views
23 (1 by ULiège)
Number of downloads
45 (1 by ULiège)

OpenCitations
 
18

Bibliography


Similar publications



Contact ORBi