Article (Scientific journals)
Age-related performance of human papillomavirus testing used as an adjunct to cytology for cervical carcinoma screening in a population with a low incidence of cervical carcinoma
Petignat, P.; Faltin, D.; Goffin, Frédéric et al.
2005In Cancer, 105 (3), p. 126-132
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Keywords :
cervical carcinoma; liquid-based cytology; Papanicolaou smear; human papillomavirus screening
Abstract :
[en] BACKGROUND. High-risk human papillomavirus (HR-HPV) testing has been proposed as a replacement for cytology or as an adjunct to cytology for primary cervical carcinoma screening. The objective of this study was to assess the age-specific prevalence of HR-HPV infection and the correlation between HR-HPV status and cytologic diagnosis. METHODS. The authors enrolled 7254 women receiving routine cytologic screening in a cross-sectional study that was conducted during 12 months. Cervical samples were collected using liquid-based cytology to perform both Papanicolaou smears and HR-HPV testing. Analyses were performed using age stratification, and the cytologic results were considered as the reference diagnosis for parameter analysis tests. RESULTS. The overall rate of HR-HPV infection was 11.4% (95% confidence interval, 9-12%) and was higher in younger women compared with older women (age < 30 years vs. >= 30 years; 16% vs. 8.5%, respectively; P < 0.0001). The overall rate of abnormal cytology was 3.2% and, similarly, was more prevalent in younger women (6.1% vs. 2.4%; P < 0.0001). The best balance between sensitivity and specificity for high-grade lesions or worse occurred predominantly in older age groups (age >= 50 years). CONCLUSIONS. The prevalence of HR-HPV was age-dependent, with the strongest correlation between HR-HPV positivity and disease observed among older women, who potentially may derive the most benefit. (c) 2005 American Cancer Society.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Oncology
Author, co-author :
Petignat, P.
Faltin, D.
Goffin, Frédéric ;  Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR
Billieux, M. H.
Stucki, D.
Sporri, S.
Vassilakos, P.
Language :
English
Title :
Age-related performance of human papillomavirus testing used as an adjunct to cytology for cervical carcinoma screening in a population with a low incidence of cervical carcinoma
Publication date :
25 June 2005
Journal title :
Cancer
ISSN :
0008-543X
eISSN :
1097-0142
Publisher :
Wiley, Hoboken, United States - New Jersey
Volume :
105
Issue :
3
Pages :
126-132
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 January 2010

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