ORBi: Quertemont Etienne - Ethanol induces taurine release in the amygdala: an in vivo microdialysis study

Reference : Ethanol induces taurine release in the amygdala: an in vivo microdialysis study


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Psychiatry Human health sciences : Pharmacy, pharmacology & toxicology Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/2268/10328

Title :	Ethanol induces taurine release in the amygdala: an in vivo microdialysis study
Language :	English
Author, co-author :	Quertemont, Etienne [Université de Liège - ULg > Département des sciences cognitives > Psychologie quantitative >]
	Dahchour, Abdelkhader [Université Catholique de Louvain - UCL > > Biologie du comportement > >]
	Ward, Roberta J. [Université Catholique de Louvain - UCL > > Biologie du comportement > >]
	De Witte, Philippe [Université Catholique de Louvain - UCL > > Biologie du comportement > >]
Publication date :	1999
Journal title :	Addiction Biology
Publisher :	Blackwell Publishing
Volume :	4
Pages :	47-54
Audience :	International
ISSN :	1355-6215
e-ISSN :	1369-1600
City :	Oxford
Country :	United Kingdom
Keywords :	[en] Taurine ; Ethanol ; Microdialysis ; Amygdala ; Glutamate ; GABA
Abstract :	[en] The effect of acute IP ethanol injections on the extracellular aspartate, glutamate, taurine and GABA content of the basolateral amygdala microdialysate was investigated in relationship with the total brain ethanol content. Each acute intraperitoneal injection of ethanol, 0.5, 1.0, 2.0 and 3.0 g/kg body weight, induced an immediate increase in the microdialysate taurine content; both 0.5 and 1.0 g/kg ethanol evoked an increase during the first 20 minutes following injection which returned to baseline value by 40 minutes despite the fact that ethanol was detectable in the brain until 60 or 120 minutes respectively; after either 2.0 or 3.0 g/kg ethanol there was an increase in taurine content of gradual intensity which gradually declined to reach baseline values by 100 minutes. In contrast, the ethanol concentration for 2.0 g/kg remained elevated at the end of the 120 minutes approximately 25 mg ethanol / mg protein. The stimulated release of taurine within the amygdala could participate in the regulation of the ethanol-induced changes in osmolarity, since taurine is postulated to act as an osmoregulator in the brain. Taurine could also mediate or interact with the ethanol-induced CNS effects, as it exerts a modulatory action on cell excitability and neurotransmitter processes.
Research units :	Centre de Neurosciences Cognitives et Comportementales
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Institut de Recherches Economiques sur les Boissons (IREB) ; LIPHA
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/10328

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