Reference : Induction of the Alternative NF-{kappa}B Pathway by Lymphotoxin {alpha}{beta} (LT{alpha}...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/103110
Induction of the Alternative NF-{kappa}B Pathway by Lymphotoxin {alpha}{beta} (LT{alpha}{beta}) Relies on Internalization of LT{beta} Receptor
English
[en] Induction de la voie NF-kappaB alternative via le récepteur de la lymphotoxine beta requière l'internalisation de son récepteur
Ganeff, Corine [ > > ]
Remouchamps, Caroline mailto [Université de Liège - ULg > > GIGA-R : Virologie - Immunologie >]
Boutaffala, Layla [ > > ]
Benezech, Cécile [ > > ]
Galopin, Géraldine [ > > ]
Vandepaer, Sarah [ > > ]
Bouillenne, fabrice [ > > ]
Ormenese, Sandra mailto [Université de Liège - ULg > > GIGA-Management : Plate-forme imagerie >]
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Schneider, Patrick [ > > ]
Caamano, Jorge [ > > ]
Piette, Jacques mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Virologie - Immunologie >]
Dejardin, Emmanuel mailto [Université de Liège - ULg > > GIGA-R : Virologie - Immunologie >]
30-Nov-2011
Molecular & Cellular Biology
American Society for Microbiology (ASM)
21
4319-4334
Yes (verified by ORBi)
International
0270-7306
1098-5549
Washington
DC
[en] NF-kappaB ; alternative pathway ; lymphotoxin beta
[en] Several tumor necrosis factor receptor (TNFR) family members activate both the classical and the alternative NF-κB pathways. However, how a single receptor engages these two distinct pathways is still poorly understood. Using lymphotoxin β receptor (LTβR) as a prototype, we showed that activation of the alternative, but not the classical, NF-κB pathway relied on internalization of the receptor. Further molecular analyses revealed a specific cytosolic region of LTβR essential for its internalization, TRAF3 recruitment, and p100 processing. Interestingly, we found that dynamin-dependent, but clathrin-independent, internalization of LTβR appeared to be required for the activation of the alternative, but not the classical, NF-κB pathway. In vivo, ligand-induced internalization of LTβR in mesenteric lymph node stromal cells correlated with induction of alternative NF-κB target genes. Thus, our data shed light on LTβR cellular trafficking as a process required for specific biological functions of NF-κB.
Giga-Signal Transduction
FNRS, TELEVIE, FCC
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/103110

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