Article (Scientific journals)
Taurine and ethanol preference : a microdialysis study using Sardinian alcohol-preferring and non-preferring rats
Quertemont, Etienne; Lallemand, Frédéric; Colombo, Giancarlo et al.
2000In European Neuropsychopharmacology, 10, p. 377-383
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Keywords :
Ethanol; Taurine; Microdialysis; Amino Acids; Alcohol-preferring rats; Alcohol-non-preferring rats
Abstract :
[en] Recent intracerebral microdialysis studies of different rat brain regions have shown that an acute ethanol injection induced a rapid dose-dependent increase in taurine microdialysate content during the first 60-min period. In taurine-supplemented rats, a reduced aversion for high ethanol doses was observed in a place conditioning paradigm, suggesting that taurine may be implicated in the regulation of some adverse effects of ethanol. The present study compares the effects of acute ethanol injections (1.0 and 2.0 g/ kg, i.p.) on taurine nucleus accumbens microdialysate content in Sardinian ethanol-preferring (sP) and Sardinian ethanol-non preferring (sNP) rats. While neither saline nor 1.0 g/kg ethanol injections had significant effect on taurine microdialysate concentration, 2.0 g/kg ethanol administration induced a rapid and significant increase in taurine microdialysate content in both sP and sNP rats. However, this ethanol-induced taurine release was significantly reduced in sP rats by comparison to sNP rats. As taurine is suggested to be released by brain cells to modulate different ethanol adverse effects, this lower taurine responsiveness to ethanol in sP rats by comparison to both sNP and Wistar rats may be a relevant indicator of reduced ethanol aversive effects in such animals and therefore be related to their higher alcohol consumption.
Research center :
Centre de Neurosciences Cognitives et Comportementales - ULiège
Disciplines :
Neurosciences & behavior
Pharmacy, pharmacology & toxicology
Psychiatry
Author, co-author :
Quertemont, Etienne  ;  Université de Liège - ULiège > Département des sciences cognitives > Psychologie quantitative
Lallemand, Frédéric;  Université Catholique de Louvain - UCL > Biologie du Comportement
Colombo, Giancarlo;  University of Cagliari > Department of Neurosciences
De Witte, Philippe;  Université Catholique de Louvain - UCL > Biologie du Comportement
Language :
English
Title :
Taurine and ethanol preference : a microdialysis study using Sardinian alcohol-preferring and non-preferring rats
Publication date :
2000
Journal title :
European Neuropsychopharmacology
ISSN :
0924-977X
eISSN :
1873-7862
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
10
Pages :
377-383
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
IREB - Institut de Recherches Scientifiques sur les Boissons [FR]
LIPHA
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