Article (Scientific journals)
Cysteamine supplementation of in vitro maturation media: a review.
Deleuze, Stefan; Goudet, Ghylene
2010In Reproduction in Domestic Animals, 45 (6), p. 476-82
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Keywords :
cysteamine; oocyte; equine
Abstract :
[en] Under in vitro culture conditions, oxidative modifications of cell components via increased reactive oxygen species (ROS) represent a major culture induced stress. Anti-oxidant systems such as glutathione (GSH) can attenuate the deleterious effects of oxidative stress by scavenging ROS. It has been suggested that GSH content in oocytes may serve as a reservoir protecting the zygote and the early embryos from oxidative damage before genomic activation and de novo GSH synthesis occur. Addition of low molecular weight compounds to culture media, such as cysteamine, can increase GSH levels by increasing cysteine uptake. Quite naturally, effects of supplementation of in vitro maturation (IVM) media with low molecular weight thiols have been studied in various species. This article reviews the use of cysteamine supplementation for IVM, its effects on maturation rates and further embryo development.
Disciplines :
Biotechnology
Veterinary medicine & animal health
Author, co-author :
Deleuze, Stefan  
Goudet, Ghylene;  Institut Scientifique de Recherche Agronomique - INRA
Language :
English
Title :
Cysteamine supplementation of in vitro maturation media: a review.
Publication date :
2010
Journal title :
Reproduction in Domestic Animals
ISSN :
0936-6768
eISSN :
1439-0531
Publisher :
Blackwell Publishing, Berlin, Germany
Volume :
45
Issue :
6
Pages :
e476-82
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2010 Blackwell Verlag GmbH.
Available on ORBi :
since 14 November 2011

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