[en] OBJECTIVE: To evaluate the hemodynamic effects of dobutamine hydrochloride (0.5 microg/kg of body weight/min) in halothane-anesthetized horses. ANIMALS: 6 adult Thoroughbred horses. PROCEDURE: Anesthesia was induced by use of romifidine (100 microg/kg) and ketamine (2.2 mg/kg), IV. Anesthesia was maintained by halothane (end-tidal concentration 0.9 to 1.0%). Aortic, left ventricular, and right atrial pressures were measured, using catheter-mounted strain gauge transducers. Cardiac output (CO), velocity time integral, maximal aortic blood flow velocity and acceleration, and left ventricular preejection period and ejection time were measured from aortic velocity waveforms obtained by transesophageal Doppler echocardiography. Velocity waveforms were recorded from the femoral vessels, using Doppler ultrasonography. The time-averaged mean velocity and early diastolic deceleration slope (EDDS) were measured. Pulsatility index (PI) and volumetric flow were calculated. Microvascular perfusion was measured in the semimembranosus muscles by laser Doppler flowmetry. Data were recorded 60 minutes after induction of anesthesia (control) and at 15 and 30 minutes after start of an infusion of dobutamine (0.5 microg/kg/min). RESULTS: Aortic pressures were significantly increased during the infusion of dobutamine. No change was observed in the indices of left ventricular systolic function including CO. Femoral arterial flow significantly increased, and the PI and EDDS decreased. No change was observed in the femoral venous flow or in microvascular perfusion. CONCLUSIONS AND CLINICAL RELEVANCE: At this dosage, dobutamine did not alter left ventricular systolic function. Femoral blood flow was preferentially increased as the result of local vasodilatation. The lack of effect of dobutamine on microvascular perfusion suggests that increased femoral flow is not necessarily associated with improved perfusion of skeletal muscles
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology Veterinary medicine & animal health
Author, co-author :
Raisis, Anthea L
Young, Lesley E
Blissitt, Karen J
Walsh, Karen
Meire, HyltonB
Taylor, PollyM
Lekeux, Pierre ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie - Doyen de la Faculté de Médecine vétérinaire
Language :
English
Title :
Effect of a 30-minute infusion of dobutamine hydrochloride on hind limb blood flow and hemodynamics in halothane-anesthetized horses
Publication date :
2000
Journal title :
American Journal of Veterinary Research
ISSN :
0002-9645
eISSN :
1943-5681
Publisher :
American Veterinary Medical Association, Schaumburg, United States - Illinois
Swanson CR, Muir WW, Bednarski RM, et al. Haemodynamic responses in halothane-anaesthetized horses given infusions of dopamine or dobutamine. Am J Vet Res 1985;46:365-370.
Lawson NW. Catecholamines: the first messengers, Clin anaesthesiol vasoactive drugs 1994;8:1-25.
Hinds JE. Hawthorne EW. Comparative cardiac dynamic effects of dobutamine and isoproterenol in conscious instrumented dogs. Am J Cardiol 1975;36:894-901.
Tuttle RR. Mills J. Dobutamine. Development of a new catecholamine to selectively increase cardiac contractility. Circ Res 1975;36:185-195.
Leier CV, Heban PT, Huss P, et al. Comparative systemic and regional haemodynamic effects of dopamine and dobutamine in patients with cardiomyopathic heart failure. Circulation 1978; 58:466-475.
Steltzer H, Owen AN, Hammerle AF. The effects of dobutamine therapy in critically ill patients measured by transesophageal echocardiography and intracardiac monitoring. Anaesthesia 1994; 49:432-437.
Leier CV, Unverferth DV. Dobutamine. Diagnosis and treatment. Drugs five years later. Ann Intern Med 1983;99:490-496.
Vainionpaa V, Nuutinen L, Kairalouma M, et al. Haemodynamic comparison of dopamine and dobutamine in normovolaemic and hypovolaemic dogs. Acta Anaesthesiol Scand 1983; 27:490-494.
Donaldson LL. Retrospective assessment of dobutamine therapy for hypotension in anaesthetised horses. Vet Surg 1988;17: 53-57.
Mizuno Y, Aida H, Fujinaga T. Effects of dobutamine infusion in dorsally recumbent isoflurane-anaesthelised horses. J Equine Sci 1994;5:87-94
Young LE, Blissitt KJ, Clutton RE, et al. Temporal effects of an infusion of dobutamine hydrochloride in horses anaesthetised with halothane. Am J Vet Res 1998;59:1027-1032.
Young SS, Taylor PM. Factors influencing the outcome of equine anaesthesia: a review of 1,314 cases. Equine Vet J 1993;25: 147-151.
Steffey EP, Howland D Jr, Giri S, et al. Enflurane, halothane, and isoflurane potency in horses. Am J Vet Res 1977;38:1037-1039.
Young LE, Blissitt KJ, Clutton RE, et al. Feasibility of transesophageal echocardiography for evaluation of left ventricular performance in anaesthetised horses. Equine Vet J Suppl 1995;19:63-70.
Young LE, Blissitt KJ, Bartram DH, et al. Measurement of cardiac output by transesophageal Doppler echocardiography in anaesthetised horses: comparison with thermodilution. Br J Anaesth 1996;77:773-780
Nichols WW, O'Rourke MF. The nature of flow of a liquid. In: McDonald's blood flow in arteries: theoretical, experimental and clinical principles, London, England: Arnold, 1998;11-53.
Raisis AL, Young LE, Meire HB, et al. Repeatability of Doppler ultrasound measurements of hindlimb blood flow in anaesthetised horses. Equine Vet J 2000;in Press.
Weissler AM, Harris WS, Schoenfeld CO. Systolic time intervals in heart failure in man. Circulation 1968;37:149-159.
Trim CM, Moore JN, White NA. Cardiopulmonary effects of dopamine hydrochloride in anaesthetised horses. Equine Vet J 1985;17:41-44.
Muir WW. Cardiovascular effects of dopexamine HCl in conscious and halothane anesthetized horses. Equine Vet J 1992; 24(suppl 11):24-29.
Zierler RE, Zierler BK. Duplex sonography of lower extremity arteries. In: Zweibel WJ, ed. Introduction to vascular ultrasonography. Philadelphia: WB Saunders Co, 1992;237-251.
Zwiebel WJ. Spectrum analysis in Doppler vascular diagnosis. In: Introduction to vascular ultrasonography. Philadelphia: WB Saunders Co, 1992;45-65.
Weaver BMQ, Lunn CEM, Staddon GE. Muscle perfusion in the horse. Equine Vet J 1984;16:66-68.
Manohar M, Gustafson R, Nganwa D. Skeletal muscle perfusion during prolonged 2.03% end-tidal isoflurane-O2 anesthesia is isocapnic ponies. Am J Vet Res 1987;48:946-951.
Lindbom L, Arfos K-E. Interrelationship between arteriolar blood flow distribution and capillary perfusion in skeletal muscle. Prog Appl Microcirc 1984;5:84-92.
Tangelder GJ, Slaaf DW, Reneman RS. Skeletal muscle microcirculation and changes in transmural and perfusion pressure. Prog Appl Microcirc 1984;5:93-108.
Lindsay WA, Pascoe PJ, McDonell WN, et al. Effect of protective padding on forelimb intracompartmental muscle pressures in anaesthetised horses. Am J Vet Res 1985;46:688-691.
White NA, Suarez M. Change in triceps muscle intracompartmental pressure with repositioning and padding of the lowermost thoracic limb of the horse. Am J Vet Res 1986;47: 2257-2260.
Kamm RD, Pedley TJ. Flow in collapsible tubes: a brief review. J Biochem Eng 1989;111:177-179.
Seymour RS, Hargens AR, Pedley TJ. The heart works against gravity. Am J Physiol 1993;265:715-720.
Peters P, Baker SR, Leopold PW, et al. Compartment syndrome following prolonged pelvic surgery. Br J Surg 1994;81: 1128-1131.
Tymyl K, Roman RJ, Lombard JH. Blood flow in skeletal muscle. In: Developments in cardiovascular medicine. Philadelphia: WB Saunders, 1990;215-226.
Lewis DH. The response of the microvasculature in skeletal muscle to haemorrhage, trauma and ischaemia. Prog Appl Microcirc 1984;5:127-138.
Wheatley AM, Hickman R. The influence of flow and haematocrit on the laser Doppler flux signal from the surface of the perfused pig liver. Microcirculation 1995;2:19-25.
Lee Y-HL, Clarke KW, Alibhai HIK, et al. Effects of dopamine, dobutamine, dopexamine, phenylephrine, and saline solution on intramuscular blood flow and other cardiopulmonary variables in halothane-anaesthetised ponies. Am J Vet Res 1998;59: 1463-1472.
