ORBi: Dahchour Abdelkhader - Taurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats

Reference : Taurine increases in the nucleus accumbens microdialysate after acute ethanol administra...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology Human health sciences : Psychiatry Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/2268/10279

Title :	Taurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats
Language :	English
Author, co-author :	Dahchour, Abdelkhader [Université Catholique de Louvain - UCL > > Biologie du comportement > >]
	Quertemont, Etienne [Université de Liège - ULg > Département des sciences cognitives > Psychologie quantitative >]
	De Witte, Philippe [Université Catholique de Louvain - UCL > > Biologie du comportement > >]
Publication date :	1996
Journal title :	Brain Research
Publisher :	Elsevier
Volume :	735
Pages :	9-19
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0006-8993
City :	Amsterdam
Country :	The Netherlands
Keywords :	[en] Ethanol ; Taurine ; Nucleus Accumbens ; Glutamate ; GABA ; Microdialysis
Abstract :	[en] The extracellular changes of amino acids glutamate, taurine and GABA in the nucleus accumbens of freely moving rats were estimated using the microdialysis technique following acute and chronic ethanol injections (1, 2, and 3 g/kg body weight). Compared to baseline values, taurine increased by 154%, 142% and 162%, 20 min after the acute injection of, respectively, 1, 2 and 3 g/kg body weight ethanol, while 40 min after ethanol injection, taurine had increased by 124%, 146% and 168%. No changes in either glutamate or GABA were detected at any time points assayed. In the rats which had received chronic ethanol administration prior to a further acute ethanol injection (1, 2, and 3 g/kg body weight), taurine increased by 138%, 144% and 180%, 20 min after the ethanol injection, and at 40 min post ethanol injection taurine had increased by 134%, 160% and 158%, compared to the basal baseline value. No significant changes were observed in either glutamate or GABA microdialysate content in these chronic studies. The biological role played by taurine after acute ethanol injection in the nucleus accumbens remains unclear but may be associated with a yet, undefined mechanism, in reducing the cytotoxicity of ethanol.
Research units :	Centre de Neurosciences Cognitives et Comportementales
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Institut de Recherche Economique sur les Boissons (IREB) ; LIPHA
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/10279

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