Reference : Structure and development of cochlear afferent innervation in mammals.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/102749
Structure and development of cochlear afferent innervation in mammals.
English
Defourny, Jean mailto [Université de Liège - ULg > > > Doct. sc. bioméd. & pharma. (Bologne)]
Lallemend, Francois [> > > >]
Malgrange, Brigitte mailto [Université de Liège - ULg > > GIGA - Neurosciences]
2011
American Journal of Physiology - Cell Physiology
American Physiological Society
301
4
C750-61
Yes (verified by ORBi)
International
0363-6143
1522-1563
Bethesda
MD
[en] inner ear ; cochlea ; innervation
[en] In mammals, sensorineural deafness results from damage to the auditory receptors of the inner ear, the nerve pathways to the brain or the cortical area that receives sound information. In this review, we first focused on the cellular and molecular events taking part to spiral ganglion axon growth, extension to the organ of Corti, and refinement. In the second half, we considered the functional maturation of synaptic contacts between sensory hair cells and their afferent projections. A better understanding of all these processes could open insights into novel therapeutic strategies aimed to re-establish primary connections from sound transducers to the ascending auditory nerve pathways.
Giga-Neurosciences
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds Léon Fredericq ; Fonds de la Recherche Scientifique Médicale - FRSM
Researchers
http://hdl.handle.net/2268/102749
10.1152/ajpcell.00516.2010

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