Reference : Cycling or not cycling: cell cycle regulatory molecules and adult neurogenesis.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/102747
Cycling or not cycling: cell cycle regulatory molecules and adult neurogenesis.
English
Beukelaers, Pierre* [Université de Liège - ULg > > > Doct. sc. bioméd. & pharma. (Bologne)]
Vandenbosch, Renaud* mailto [Université de Liège - ULg > > GIGA - Neurosciences]
Caron, Nicolas mailto [Université de Liège - ULg > > GIGA - Neurosciences]
Nguyen, Laurent mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie]
Moonen, Gustave mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie]
Malgrange, Brigitte mailto [Université de Liège - ULg > > GIGA - Neurosciences]
* These authors have contributed equally to this work.
2012
Cellular and Molecular Life Sciences : CMLS
Birkhäuser
69
9
1493-1503
Yes
International
1420-682X
1420-9071
Basel
Switzerland
[en] stem cells ; neurogenesis ; adult brain
[en] The adult brain most probably reaches its highest degree of plasticity with the lifelong generation and integration of new neurons in the hippocampus and olfactory system. Neural precursor cells (NPCs) residing both in the subgranular zone of the dentate gyrus and in the subventricular zone of the lateral ventricles continuously generate neurons that populate the dentate gyrus and the olfactory bulb, respectively. The regulation of NPC proliferation in the adult brain has been widely investigated in the past few years. Yet, the intrinsic cell cycle machinery underlying NPC proliferation remains largely unexplored. In this review, we discuss the cell cycle components that are involved in the regulation of NPC proliferation in both neurogenic areas of the adult brain.
Giga-Neurosciences
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds Léon Fredericq
Researchers
http://hdl.handle.net/2268/102747
10.1007/s00018-011-0880-6

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