ORBi: Quertemont Etienne - Role of catalase in ethanol-induced conditioned taste aversion : a study with 3-amino-1,2,4-triazole

Reference : Role of catalase in ethanol-induced conditioned taste aversion : a study with 3-amino-1,...


	Document type :	Scientific journals : Article
	Discipline(s) :	Social & behavioral sciences, psychology : Neurosciences & behavior Human health sciences : Psychiatry Human health sciences : Pharmacy, pharmacology & toxicology
	To cite this reference:	http://hdl.handle.net/2268/10274

Title :	Role of catalase in ethanol-induced conditioned taste aversion : a study with 3-amino-1,2,4-triazole
Language :	English
Author, co-author :	Quertemont, Etienne [Université de Liège - ULg > Département des sciences cognitives > Psychologie quantitative >]
	Escarabajal, M. Dolores [Universidad de Jaen > > Area de Psicobiologia > >]
	De Witte, Philippe [Université Catholique de Louvain - UCL > > Biologie du Comportement > >]
Publication date :	2003
Journal title :	Drug and Alcohol Dependence
Publisher :	Elsevier Sci Ireland Ltd
Volume :	70
Issue/season :	1
Pages :	77-83
Audience :	International
ISSN :	0376-8716
City :	Clare
Keywords :	[en] ethanol ; 3-amino-1,2,4-triazole ; catalase ; conditioned taste aversion ; microdialysis ; acetaldehyde
Abstract :	[en] Recent studies involved acetaldehyde, the first ethanol metabolite, in both the rewarding and aversive effects of ethanol consumption. Brain acetaldehyde is believed to originate mainly from local brain metabolism of ethanol by the enzyme catalase. Therefore, the inhibition of catalase by 3-amino-1,2,4-triazole (aminotriazole) may help to clarify the involvement of acetaldehyde in ethanol's hedonic effects. In the present study, multiple doses of both ethanol and aminotriazole were used to investigate the effects of catalase inhibition on ethanol-induced conditioned taste aversion (CTA). A separate microdialysis experiment investigated the effects of aminotriazole pretreatment on the time course of brain ethanol concentrations. Ethanol induced a dose-dependent CTA with a maximal effect after conditioning with 2.0 g/kg ethanol. Aminotriazole pretreatments dose-dependently potentiated the CTA induced by 1.0 g/kg ethanol. However, aminotriazole pretreatments did not alter the CTA induced by higher ethanol doses (1.5 and 2.0 g/kg) probably because a maximal aversion for saccharin was already obtained without aminotriazole. The results of the microdialysis experiment confirmed that the effects of aminotriazole cannot be attributed to local alterations of brain ethanol levels. The present study argues against a role for brain acetaldehyde in ethanol's aversive effects but in favor of its involvement in ethanol rewarding properties. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Research units :	Centre de Neurosciences Cognitives et Comportementales
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Institut de Recherches Economiques (IREB) ; LIPHA
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/10274

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