ORBi: Balentova Eva - Synthesis and hydrolytic stability of novel 3-[18F]fluoroethoxybis(1-methylethyl)silyl]propanamine-based prosthetic groups

Reference : Synthesis and hydrolytic stability of novel 3-[18F]fluoroethoxybis(1-methylethyl)silyl]p...


	Document type :	Scientific journals : Article
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry
	To cite this reference:	http://hdl.handle.net/2268/102598

Title :	Synthesis and hydrolytic stability of novel 3-[18F]fluoroethoxybis(1-methylethyl)silyl]propanamine-based prosthetic groups
Language :	English
Author, co-author :	Balentova, Eva [ > > ]
	Collet, Charlotte [ > > ]
	Lamande-Langle, Sandrine [ > > ]
	Chretien, Françoise [ > > ]
	Thonon, David [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Aerts, Joël [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Lemaire, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Luxen, André [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse >]
	Chapleur, Yves [ > > ]
Publication date :	2011
Journal title :	Journal of Fluorine Chemistry
Publisher :	Elsevier Science
Volume :	132
Issue/season :	4
Pages :	250-257
Audience :	International
ISSN :	0022-1139
Abstract :	[en] Two new silicon-based prosthetic groups, derived from 3-[ethoxybis(1-methylethyl)silyl]propanamine, have been prepd. in good yields. These silicon groups bearing an acid or an azide group were coupled to a model tripeptide (Leu-Gly- Gly) either through a classical amide bond formation or through "click chem." via the Huisgen cycloaddn. The radiolabeling with fluorine-18 by substitution of the ethoxy group at silicon has been carried out with success in 51-54% decay cor. radiochem. yields. Radiolabeled peptides were easily prepd. by direct 18F-fluorination of the silicon-bearing tripeptide or by coupling the peptide with a radiolabeled silicon-based prosthetic group. Their stabilities in physiol. medium were studied and proved poor.
Permalink :	http://hdl.handle.net/2268/102598
DOI :	10.1016/j.jfluchem.2011.01.011

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