|Reference : Synthesis and hydrolytic stability of novel 3-[18F]fluoroethoxybis(1-methylethyl)silyl]p...|
|Scientific journals : Article|
|Physical, chemical, mathematical & earth Sciences : Chemistry|
|Synthesis and hydrolytic stability of novel 3-[18F]fluoroethoxybis(1-methylethyl)silyl]propanamine-based prosthetic groups|
|Balentova, Eva [ > > ]|
|Collet, Charlotte [ > > ]|
|Lamande-Langle, Sandrine [ > > ]|
|Chretien, Françoise [ > > ]|
|Thonon, David [Université de Liège - ULg > > Centre de recherches du cyclotron >]|
|Aerts, Joël [Université de Liège - ULg > > Centre de recherches du cyclotron >]|
|Lemaire, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]|
|Luxen, André [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse >]|
|Chapleur, Yves [ > > ]|
|Journal of Fluorine Chemistry|
|Yes (verified by ORBi)|
|[en] Two new silicon-based prosthetic groups, derived from 3-[ethoxybis(1-methylethyl)silyl]propanamine, have been prepd.
in good yields. These silicon groups bearing an acid or an azide group were coupled to a model tripeptide (Leu-Gly-
Gly) either through a classical amide bond formation or through "click chem." via the Huisgen cycloaddn. The
radiolabeling with fluorine-18 by substitution of the ethoxy group at silicon has been carried out with success in 51-54%
decay cor. radiochem. yields. Radiolabeled peptides were easily prepd. by direct 18F-fluorination of the silicon-bearing
tripeptide or by coupling the peptide with a radiolabeled silicon-based prosthetic group. Their stabilities in physiol.
medium were studied and proved poor.
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