Reference : Enhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gen...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/102261
Enhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gene inactivation.
English
Maquoi, Erik mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Demeulemeester, Diego [ > > ]
Vörös, Gabor [ > > ]
Collen, Désiré [ > > ]
Lijnen, Roger [ > > ]
Apr-2003
Thrombosis and Haemostasis
Schattauer Gmbh-Verlag Medizin Naturwissenschaften
89
4
696-704
Yes (verified by ORBi)
International
0340-6245
Stuttgart
Germany
[en] Protease ; obesity ; adipose tissue
[en] To investigate a potential role of stromelysin-1 (MMP-3) in development of adipose tissue, 5 week old male MMP-3 deficient mice (MMP-3(-/-)) and wild-type (MMP-3(+/+)) controls were kept on a high fat diet (HFD) for 15 weeks. MMP-3(-/-) mice were hyperphagic and gained more weight than the MMP-3(+/+) mice. At the time of sacrifice, the body weight of the MMP-3(-/-) mice was significantly higher than that of the MMP-3(+/+) mice, as was the weight of the isolated subcutaneous (SC) and gonadal (GON) fat deposits. Significant adipocyte hypertrophy was observed in the GON but not in the SC adipose tissue of MMP-3(-/-) mice. Fasting plasma glucose and cholesterol levels were comparable in both genotypes, whereas triglyceride levels were significantly lower in MMP-3(-/-) mice. Staining with an endothelial cell specific lectin revealed a significantly higher blood vessel density and larger total stained area in the GON adipose tissues of MMP-3(-/-) mice. Thus, in a murine model of nutritionally induced obesity, MMP-3 impairs adipose tissue development, possibly by affecting food intake and/or adipose tissue-related angiogenesis.
http://hdl.handle.net/2268/102261

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