Reference : Methylation analysis of the imprinted DLK1-GTL2 domain supports the random parental o...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/102250
Methylation analysis of the imprinted DLK1-GTL2 domain supports the random parental origin of the IGH-involving del(14q) in B-cell malignancies.
English
Katrincsakova, Beata [> > > >]
Takeda, Haruko mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Urbankova, Helena [> > > >]
Michaux, Lucienne [> > > >]
Jarosova, Marie [> > > >]
Vandenberghe, Peter [> > > >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Charlier, Carole mailto [> > > >]
Wlodarska, Iwona [ > > ]
2009
Epigenetics : Official Journal of the DNA Methylation Society
4
7
469-75
Yes
International
1559-2294
1559-2308
[en] Alleles ; Base Sequence ; Chromosomes, Human, Pair 14 ; Female ; Genes, Immunoglobulin Heavy Chain ; Humans ; Intercellular Signaling Peptides and Proteins/analysis/genetics/metabolism ; Leukemia, B-Cell/genetics/immunology/metabolism ; Lymphoma, B-Cell/chemistry/genetics/immunology/metabolism ; Male ; Membrane Proteins/analysis/genetics/metabolism ; Methylation ; Parents ; Proteins/analysis/genetics/metabolism
[en] Leukemias/lymphomas with IGH-involving del(14q)(1) commonly lose the DLK1-GTL2 imprinted domain that comprises several paternally and maternally expressed genes, including a cluster of microRNAs. Given that deletion of this region could lead to inactivation of a monoallelically expressed tumor suppressor gene, our study aimed at determination of the parental origin of del(14q/IGH). The designed allele-specific methylation study of the DLK1/GTL2 intergenic differentially methylated region allowed us to determine the parental origin of del(14q/IGH) in 9/20 analyzed cases. In six cases del(14q/IGH) was of the paternal origin and in three cases of the maternal origin. These findings argue against the concept that a TSG/anti-oncomir located in the imprinted region is systematically inactivated by a targeted deletion of its functional allele.
Researchers ; Professionals
http://hdl.handle.net/2268/102250

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
KatrincsakovaEPI4-7.pdfPublisher postprint7.67 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.