Reference : Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and dis...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/102219
Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease.
English
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Coppieters, Wouter mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Charlier, Carole mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
2007
Current opinion in genetics & development
17
3
166-76
Yes (verified by ORBi)
International
0959-437X
England
[en] Animals ; Disease ; Gene Expression Regulation/genetics ; Genetic Variation/genetics ; Humans ; MicroRNAs/genetics ; Phenotype ; Polymorphism, Genetic/genetics
[en] The expression of at least a third of mammalian genes is post-transcriptionally fine-tuned by approximately 1000 microRNAs (miRNAs), assisted by the RNA silencing machinery, comprising tens of components. Polymorphisms and mutations in the corresponding sequence space (machinery, miRNA precursors and target sites) are likely to make a significant contribution to phenotypic variation, including disease susceptibility. Here we review basic miRNA biology in animals, survey the available evidence for DNA sequence polymorphisms affecting miRNA-mediated gene regulation and thus phenotype, and discuss their possible importance in the determination of complex traits.
Researchers ; Professionals
http://hdl.handle.net/2268/102219
10.1016/j.gde.2007.04.005

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