Reference : Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in th...
Scientific journals : Article
Life sciences : Genetics & genetic processes
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/101934
Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype.
English
Smit, Maria [> > > >]
SEGERS, Karin mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique]
Carrascosa, Laura Garcia [> > > >]
Shay, Tracy [> > > >]
Baraldi, Francesca [> > > >]
Gyapay, Gabor [> > > >]
Snowder, Gary [> > > >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Cockett, Noelle [> > > >]
Charlier, Carole mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
2003
Genetics
163
1
453-6
Yes (verified by ORBi)
International
0016-6731
United States
[en] Animals ; Base Sequence ; Molecular Sequence Data ; Mosaicism/genetics ; Muscular Diseases/genetics ; Point Mutation ; Sheep/abnormalities/genetics
[en] To identify the callipyge mutation, we have resequenced 184 kb spanning the DLK1-, GTL2-, PEG11-, and MEG8-imprinted domain and have identified an A-to-G transition in a highly conserved dodecamer motif between DLK1 and GTL2. This was the only difference found between the callipyge (CLPG) allele and a phylogenetically closely related wild-type allele. We report that this SNP is in perfect association with the callipyge genotype. The demonstration that Solid Gold-the alleged founder ram of the callipyge flock-is mosaic for this SNP virtually proves the causality of this SNP in the determinism of the callipyge phenotype.
Researchers ; Professionals
http://hdl.handle.net/2268/101934
also: http://hdl.handle.net/2268/102205

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