[en] The callipyge (CLPG) gene was fine-mapped by linkage analysis to a 4.6-cM chromosome interval on distal ovine OAR18q, flanked by microsatellite markers IDVGA30 and OY3. The OAR18q linkage map and human HSA14q transcript map were aligned by genotyping two bovine-hamster whole-genome radiation hybrid panels with the microsatellite markers, as well as with sequences corresponding to HSA 14q genes. Using Type I loci mapping to the IDVGA30-OY3 interval as anchor points, we have constructed a 1.4-Mb bovine BAC contig containing the IDVGA30-OY3 interval. We demonstrate that the IDVGA30-OY3 interval spans approximately 770 kb and contains at least four genes: YY1, WARS, DLK1, and GTL2.
Disciplines :
Genetics & genetic processes
Author, co-author :
Shay, T. L.
Berghmans, S.
SEGERS, Karin ; Centre Hospitalier Universitaire de Liège - CHU > Génétique
Meyers, S.
Beever, J. E.
Womack, J. E.
Cockett, N. E.
Georges, Michel ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Charlier, Carole ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Language :
English
Title :
Fine-mapping and construction of a bovine contig spanning the ovine callipyge locus.
Publication date :
2001
Journal title :
Mammalian Genome
ISSN :
0938-8990
eISSN :
1432-1777
Publisher :
Springer Verlag, New York, United States - New York
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