ORBi: Dunner S. - Towards interbreed IBD fine mapping of the mh locus: double-muscling in the Asturiana de los Valles breed involves the same locus as in the Belgian Blue cattle breed.

Reference : Towards interbreed IBD fine mapping of the mh locus: double-muscling in the Asturiana de...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Genetics & genetic processes
	To cite this reference:	http://hdl.handle.net/2268/102186

Title :	Towards interbreed IBD fine mapping of the mh locus: double-muscling in the Asturiana de los Valles breed involves the same locus as in the Belgian Blue cattle breed.
Language :	English
Author, co-author :	Dunner, S. [> > > >]
	Charlier, Carole [Université de Liège - ULg > Département de productions animales > Biostatistiques et bioinformatique appliquées aux sc. vétér.]
	Farnir, Frédéric [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement]
	Brouwers, Benoît [> > > >]
	Canon, J. [Université de Liège - ULg > > CSL (Centre Spatial de Liège)]
	Georges, Michel [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Publication date :	1997
Journal title :	Mammalian Genome : Official Journal of the International Mammalian Genome Society
Publisher :	Springer Verlag
Volume :	8
Issue/season :	6
Pages :	430-5
Audience :	International
ISSN :	0938-8990
e-ISSN :	1432-1777
City :	New York
Country :	NY
Keywords :	[en] Animals ; Belgium ; Breeding ; Cattle/genetics ; Chromosome Mapping ; Chromosomes ; Female ; Genetic Linkage/genetics ; Genetic Markers ; Hypertrophy/genetics ; Linkage Disequilibrium ; Male ; Microsatellite Repeats ; Muscles/abnormalities ; Spain
Abstract :	[en] The Spanish "Asturiana" cattle breed is characterized by the segregation of a genetically determined muscular hypertrophy referred to as double-muscling or "culones". We demonstrate by linkage analysis that this muscular hypertrophy involves the mh locus previously shown to cause double-muscling in the Belgian Blue cattle breed, pointing towards locus homogeneity of this trait across both breeds. Moreover, using a twopoint and multipoint maximum likelihood approach, we show that flanking microsatellite markers are in linkage disequilibrium with the mh locus in both breeds albeit with different alleles. Finally, we discuss how allelic homogeneity across breeds might be exploited to achieve efficient genetic fine-mapping of the mh locus.
Permalink :	http://hdl.handle.net/2268/102186

There is no file associated with this reference.

All documents in ORBi are protected by a user license.

Dspace v1.5