Reference : The role of the bovine growth hormone receptor and prolactin receptor genes in milk, fat...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/101948
The role of the bovine growth hormone receptor and prolactin receptor genes in milk, fat and protein production in Finnish Ayrshire dairy cattle.
English
Viitala, Sirja [> > > >]
Szyda, Joanna [> > > >]
Blott, Sarah [> > > >]
Schulman, Nina [> > > >]
Lidauer, Martin [> > > >]
Maki-Tanila, Asko [> > > >]
Georges, Michel mailto [> > > >]
Vilkki, Johanna [> >]
2006
Genetics
173
4
2151-64
Yes (verified by ORBi)
International
0016-6731
United States
[en] Amino Acid Substitution ; Animals ; Base Sequence ; Cattle ; Fats ; Female ; Milk ; Milk Proteins/genetics ; Molecular Sequence Data ; Polymorphism, Genetic ; Protein Structure, Tertiary/genetics ; Quantitative Trait Loci/genetics ; Receptors, Prolactin/genetics ; Receptors, Somatotropin/genetics
[en] We herein report new evidence that the QTL effect on chromosome 20 in Finnish Ayrshire can be explained by variation in two distinct genes, growth hormone receptor (GHR) and prolactin receptor (PRLR). In a previous study in Holstein-Friesian dairy cattle an F279Y polymorphism in the transmembrane domain of GHR was found to be associated with an effect on milk yield and composition. The result of our multimarker regression analysis suggests that in Finnish Ayrshire two QTL segregate on the chromosomal region including GHR and PRLR. By sequencing the coding sequences of GHR and PRLR and the sequence of three GHR promoters from the pooled samples of individuals of known QTL genotype, we identified two substitutions that were associated with milk production traits: the previously reported F-to-Y substitution in the transmembrane domain of GHR and an S-to-N substitution in the signal peptide of PRLR. The results provide strong evidence that the effect of PRLR S18N polymorphism is distinct from the GHR F279Y effect. In particular, the GHR F279Y has the highest influence on protein percentage and fat percentage while PRLR S18N markedly influences protein and fat yield. Furthermore, an interaction between the two loci is suggested.
Researchers ; Professionals
http://hdl.handle.net/2268/101948
also: http://hdl.handle.net/2268/102126
10.1534/genetics.105.046730

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