Article (Scientific journals)
Measuring the extent of linkage disequilibrium in commercial pig populations
Harmegnies, Natacha; Farnir, Frédéric; DAVIN, Fabienne et al.
2006In Animal Genetics, 37 (3), p. 225-231
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Keywords :
Alleles; Animals; Chromosome Mapping; Chromosomes, Mammalian; effective population size; Genotype; linkage disequilibrium; pigs; Population Density; Swine/genetics
Abstract :
[en] To evaluate the extent of linkage disequilibrium in domestic pigs, we genotyped 33 and 44 unrelated individuals from two commercial populations for 29 and five microsatellite markers located on chromosomes 15 and 2 respectively. A high proportion of marker pairs up to 40 cM apart exhibited significant linkage disequilibrium in both populations. Pair-wise r(2) values averaged between 0.15 and 0.50 (depending on chromosome and population) for markers < 1 cM apart and declined to values of 0.05 for more distant syntenic markers. Our results suggest that both populations underwent a bottleneck approximately 20 generations ago, which reduced the effective population size from thousands to < 200 animals.
Disciplines :
Genetics & genetic processes
Zoology
Agriculture & agronomy
Author, co-author :
Harmegnies, Natacha ;  Université de Liège - ULiège > Département de gestion vétérinaire des Ressources Animales (DRA) > GIGA-R : Génomique animale
Farnir, Frédéric  ;  Université de Liège - ULiège > Département de productions animales > Biostatistique, économie, sélection animale
DAVIN, Fabienne ;  Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Buys, N.
Georges, Michel   ;  Université de Liège - ULiège > Département de productions animales > Génomique animale
Coppieters, Wouter  ;  Université de Liège - ULiège > Département de productions animales > Département de productions animales
 These authors have contributed equally to this work.
Language :
English
Title :
Measuring the extent of linkage disequilibrium in commercial pig populations
Publication date :
2006
Journal title :
Animal Genetics
ISSN :
0268-9146
eISSN :
1365-2052
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
37
Issue :
3
Pages :
225-231
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 November 2011

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