ORBi: Harmegnies N. - Measuring the extent of linkage disequilibrium in commercial pig populations

Reference : Measuring the extent of linkage disequilibrium in commercial pig populations


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Zoology Life sciences : Genetics & genetic processes Life sciences : Agriculture & agronomy
	To cite this reference:	http://hdl.handle.net/2268/102124

Title :	Measuring the extent of linkage disequilibrium in commercial pig populations
Language :	English
Author, co-author :	Harmegnies, N. [> > > >]
	Farnir, Frédéric [Université de Liège - ULg > Département de productions animales > Biostatistique, économie, sélection animale >]
	Davin, Fabienne [Centre Hospitalier Universitaire de Liège - CHU > > Centre de diagnostic moleculaire >]
	Buys, N. [> > > >]
	Georges, Michel [Université de Liège - ULg > Département de productions animales > Génomique animale >]
	Coppieters, Wouter [Université de Liège - ULg > Département de productions animales > Département de productions animales >]
Publication date :	Jun-2006
Journal title :	Animal Genetics
Publisher :	Blackwell Publishing
Volume :	37
Issue/season :	3
Pages :	225-231
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0268-9146
City :	Oxford
Keywords :	[en] effective population size ; linkage disequilibrium ; pigs
Abstract :	[en] To evaluate the extent of linkage disequilibrium in domestic pigs, we genotyped 33 and 44 unrelated individuals from two commercial populations for 29 and five microsatellite markers located on chromosomes 15 and 2 respectively. A high proportion of marker pairs up to 40 cM apart exhibited significant linkage disequilibrium in both populations. Pair-wise r(2) values averaged between 0.15 and 0.50 (depending on chromosome and population) for markers < 1 cM apart and declined to values of 0.05 for more distant syntenic markers. Our results suggest that both populations underwent a bottleneck approximately 20 generations ago, which reduced the effective population size from thousands to < 200 animals.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/102124
DOI :	10.1111/j.1365-2052.2006.01438.x

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