Reference : Positional candidate cloning of a QTL in dairy cattle: Identification of a missense m...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/102074
Positional candidate cloning of a QTL in dairy cattle: Identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition
English
Grisart, B. [> > > >]
Coppieters, Wouter mailto [Université de Liège - ULg > Département de productions animales > Département de productions animales >]
Farnir, Frédéric mailto [Université de Liège - ULg > Département de productions animales > Biostatistique, économie, sélection animale >]
Karim, Latifa mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Ford, C. [> > > >]
Berzi, P. [> >]
Cambisano, Nadine mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Mni, Myriam mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Reid, S. [> > > >]
Simon, P. [> >]
Spelman, R. [> > > >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Snell, R. [> > > >]
2002
Genome Research
Cold Spring Harbor Lab Press
12
2
222-231
Yes (verified by ORBi)
International
1088-9051
Plainview
[en] We recently mapped a quantitative trait locus (QTL) with a major effect on milk composition-particularly fat content-to the centromeric end of bovine chromosome 14. We subsequently exploited linkage disequilibrium to refine the map position of this QTL to a 3-cM chromosome interval bounded by microsatellite markers BULGE13 and BULGE09. We herein report the positional candidate cloning of this QTL, involving (I) the construction of a BAC contig spanning the corresponding marker interval, (2) the demonstration that a very strong candidate gene, acylCoA:diacylglycerol acyltransferase (DGATf), maps to that contig, and (3) the identification of a nonconservative K232A substitution in the DGAT1 gene with a major effect on milk fat content and other milk characteristics.
Researchers ; Professionals
http://hdl.handle.net/2268/102074

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