Reference : Lymphangiogenesis in post-natal tissue remodeling: Lymphatic endothelial cell connection...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/102072
Lymphangiogenesis in post-natal tissue remodeling: Lymphatic endothelial cell connection with its environment.
English
Paupert, Jenny mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Sounni, Nor Eddine mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
2011
Molecular Aspects of Medicine
Elsevier Science
32
2
146-158
Yes (verified by ORBi)
International
0098-2997
Oxford
United Kingdom
[en] Lymphangiogenesis ; Extracellular matrix ; Interstitial tissue ; Cell–cell junctions ; Integrins ; Metalloproteases
[en] The main physiological function of the lymphatic vasculature is to maintain tissue fluid homeostasis. Lymphangiogenesis or de novo lymphatic formation is closely associated with tissue inflammation in adults (i.e. wound healing, allograft rejection, tumor metastasis). Until recently, research on lymphangiogenesis focused mainly on growth factor/growth factor-receptor pathways governing this process. One of the lymphatic vessel features is the incomplete or absence of basement membrane. This close association of endothelial cells with the underlying interstitial matrix suggests that cell-matrix interactions play an important role in lymphangiogenesis and lymphatic functions. However, the exploration of interaction between extracellular matrix (ECM) components and lymphatic endothelial cells is in its infancy. Herein, we describe ECM-cell and cell-cell interactions on lymphatic system function and their modification occurring in pathologies including cancer metastasis.
http://hdl.handle.net/2268/102072
also: http://hdl.handle.net/2268/93403
10.1016/j.mam.2011.04.002

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