Reference : What role is there for antithymocyte globulin in allogeneic nonmyeloablative canine hema...
Scientific journals : Article
Human health sciences : Hematology
http://hdl.handle.net/2268/102052
What role is there for antithymocyte globulin in allogeneic nonmyeloablative canine hematopoietic cell transplantation?
English
Diaconescu, Razvan [> > > >]
Little, Marie-Terese [> > > >]
Leisenring, Wendy [> > > >]
Yunusov, Murad [> > > >]
Hogan, William J [> > > >]
Sorror, Mohamed L [> > > >]
Baron, Frédéric mailto [Université de Liège - ULg > Département des sciences cliniques > GIGA-R : Hématologie - Département des sciences cliniques >]
Storb, Rainer [> > > >]
2005
Biology of Blood & Marrow Transplantation
Carden Jennings Publishing
11
5
335-44
Yes (verified by ORBi)
International
1083-8791
1523-6536
Charlottesville
VA
[en] Animals ; Antilymphocyte Serum/therapeutic use ; Bone Marrow Transplantation ; Dogs ; Graft Rejection ; Graft Survival ; Hematopoietic Stem Cell Transplantation/methods ; Immunosuppressive Agents/therapeutic use ; Models, Animal ; Transplantation Chimera ; Transplantation Conditioning/methods ; Transplantation, Homologous ; Whole-Body Irradiation
[en] We investigated whether pretransplantation immunosuppression with canine-specific rabbit antithymocyte globulin (ATG), combined with a suboptimal dose of 1 Gy of total body irradiation (TBI), would permit engraftment of canine dog leukocyte antigen-identical marrow. Cumulative ATG doses of 2 to 5 mg/kg produced a T-cell depletion of 1 log in the peripheral blood and 50% in the lymph nodes. Serum levels of ATG peaked on days 4 to 6 after initiation of therapy and became undetectable by day 13 as a result of canine antibody responses to ATG. ATG prolonged allogeneic skin graft survival to 14 days (n = 5), compared with 8 days in control dogs (P = .0003). Five dogs were given marrow transplants after ATG (3.5-5 mg/kg) and 1 Gy of TBI. Posttransplantation immunosuppression consisted of mycophenolate mofetil and cyclosporine. All dogs showed initial engraftment, with maximum donor chimerism levels of 25%. However, only 1 dog achieved sustained engraftment, and 4 rejected their grafts. The duration of engraftment ranged from 8 to > or = 36 weeks (median, 11 weeks), and this is comparable to that in 6 historical controls not given ATG (range, 3-12 weeks; median, 10 weeks; P = .20). The total nucleated cell doses in the marrow grafts had the highest correlation coefficient with the duration of engraftment: 0.82 (P = .09). We concluded that administering ATG before an otherwise suboptimal conditioning dose of 1 Gy of TBI failed to secure uniform stable hematopoietic engraftment.
http://hdl.handle.net/2268/102052
10.1016/j.bbmt.2005.01.001

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