Reference : Chimerism and outcomes after allogeneic hematopoietic cell transplantation following non...
Scientific journals : Other
Human health sciences : Hematology
Human health sciences : Oncology
http://hdl.handle.net/2268/102026
Chimerism and outcomes after allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning
English
Baron, Frédéric mailto [Université de Liège - ULg > Département des sciences cliniques > Hématologie]
Sandmaier, B. M. [> > > >]
Oct-2006
Leukemia
Nature Publishing Group
20
10
1690-1700
Yes (verified by ORBi)
International
0887-6924
London
[en] hematopoietic cell transplantation ; nonmyeloablative conditioning ; donor chimerism ; T-cells ; NK cells
[en] Allogeneic hematopoietic cell transplantation ( HCT) following nonmyeloablative conditioning has been extensively evaluated in patients with hematologic malignancies who are ineligible for conventional HCT because of age or medical comorbidities. Nonmyeloablative regimens have led to an initial state of mixed hematopoietic chimerism defined as coexistence of donor- and host-derived hematopoiesis. While nonmyeloablative regimens have been associated with reduced regimen-related toxicities in comparison with conventional myeloablative conditioning, graft rejection, graft-versus-host disease ( GVHD), and disease progression have remained significant challenges. In this article, after briefly introducing current techniques for chimerism assessment, we describe factors affecting donor chimerism levels after nonmyeloablative conditioning, and then review data suggesting that chimerism assessment early after HCT might help identify patients at risk for graft rejection, GVHD and relapse/progression. Finally, we discuss how these observations have opened the way to further research protocols evaluating manipulation of postgrafting immunosuppression, and/or infusion of donor immune cells.
http://hdl.handle.net/2268/102026

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