Reference : High doses of transplanted CD34(+) cells are associated with rapid T-cell engraftment an...
Scientific journals : Article
Human health sciences : Hematology
Human health sciences : Oncology
http://hdl.handle.net/2268/102024
High doses of transplanted CD34(+) cells are associated with rapid T-cell engraftment and lessened risk of graft rejection, but not more graft-versus-host disease after nonmyeloablative conditioning and unrelated hematopoietic cell transplantation
English
Baron, Frédéric mailto [Université de Liège - ULg > Département des sciences cliniques > Hématologie]
Maris, M. B. [> > > >]
Storer, B. E. [> > > >]
Sandmaier, B. M. [> > > >]
Panse, J. P. [> > > >]
Chauncey, T. R. [> > > >]
Sorror, M. [> > > >]
Little, M. T. [> > > >]
Maloney, D. G. [> > > >]
Storb, R. [> > > >]
Heimfeld, S. [> > > >]
May-2005
Leukemia
Nature Publishing Group
19
5
822-828
Yes (verified by ORBi)
International
0887-6924
London
[en] cell dose ; CD34 ; T-cell ; transplantation ; nonmyeloablative
[en] This report examines the impact of graft composition on outcomes in 130 patients with hematological malignancies given unrelated donor granulocyte-colony-stimulating-factor-mobilized peripheral blood mononuclear cells (G-PBMC) ( n = 116) or marrow ( n = 14) transplantation after nonmyeloablative conditioning with 90 mg/m(2) fludarabine and 2Gy TBI. The median number of CD34(+) cells transplanted was 6.5 x 10(6)/ kg. Higher numbers of grafted CD14(+) ( P = 0.0008), CD3(+) ( P = 0.0007), CD4(+) ( P = 0.001), CD8(+) ( P = 0.004), CD3 - CD56(+) ( P = 0.003), and CD34(+) ( P = 0.0001) cells were associated with higher levels of day 28 donor T-cell chimerism. Higher numbers of CD14(+) ( P = 0.01) and CD34(+) ( P = 0.0003) cells were associated with rapid achievement of complete donor T-cell chimerism, while high numbers of CD8(+) ( P = 0.005) and CD34(+) ( P = 0.01) cells were associated with low probabilities of graft rejection. When analyses were restricted to G-PBMC recipients, higher numbers of grafted CD34(+) cells were associated with higher levels of day 28 donor T-cell chimerism ( P = 0.01), rapid achievement of complete donor T-cell chimerism ( P = 0.02), and a trend for lower risk for graft rejection ( P = 0.14). There were no associations between any cell subsets and acute or chronic GVHD nor relapse/progression. These data suggest more rapid engraftment of donor T cells and reduced rejection rates could be achieved by increasing the doses of CD34(+) cells in unrelated grafts administered after nonmyeloablative conditioning.
http://hdl.handle.net/2268/102024

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