Reference : Highly effective SNP-based association mapping and management of recessive defects in...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/101985
Highly effective SNP-based association mapping and management of recessive defects in livestock.
English
Charlier, Carole mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Coppieters, Wouter mailto [Université de Liège - ULg > Département de productions animales > Département de productions animales]
Rollin, Frédéric mailto [Université de Liège - ULg > Département clinique des animaux de production (DCP) > Médecine interne des équidés, des ruminants et des porcs]
Desmecht, Daniel mailto [Université de Liège - ULg > Département de morphologie et pathologie > Pathologie spéciale et autopsies]
Agerholm, Jorgen S [> > > >]
Cambisano, Nadine mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Carta, Eloisa [> > > >]
Dardano, Sabrina [> > > >]
Dive, Marc [> > > >]
Fasquelle, Corinne mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine]
Frennet, Jean*-Claude [> > > >]
Hanset, Roger [> > > >]
Hubin, Xavier [> > > >]
Jorgensen, Claus [> > > >]
Karim, Latifa mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire]
Kent, Matthew [> > > >]
Harvey, Kirsten [> > > >]
Pearce, Brian R [> > > >]
Simon, Patricia mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines]
Tamma, Nico mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Nie, Haisheng [> > > >]
Vandeputte, Sébastien mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Epidémiologie et analyse des risques appl. aux sc. vétér.]
Lien, Sigbjorn [> > > >]
Longeri, Maria [> > > >]
Fredholm, Merete [> > > >]
Harvey, Robert J [> > > >]
Georges, Michel mailto [ > > ]
2008
Nature Genetics
Nature Publishing Group
40
4
449-54
Yes (verified by ORBi)
International
1061-4036
1546-1718
New York
NY
[en] ATP-Binding Cassette Transporters/genetics ; Amino Acid Sequence ; Animals ; Animals, Domestic/genetics/growth & development ; Breeding ; Cattle ; Cattle Diseases/genetics ; Cells, Cultured ; Chromosome Mapping ; DNA Primers/chemistry ; Dystonia/congenital/genetics/veterinary ; Female ; Gene Expression Profiling ; Genes, Recessive/genetics ; Genetic Linkage ; Genetic Markers/genetics ; Glycine Plasma Membrane Transport Proteins/genetics ; Humans ; Male ; Molecular Sequence Data ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics ; Sequence Homology, Amino Acid
[en] The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of these: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practice, allowing marker assisted selection against the defects through avoidance of at-risk matings.
Researchers ; Professionals
http://hdl.handle.net/2268/101985
10.1038/ng.96

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