ORBi: Charlier Carole - Highly effective SNP-based association mapping and management of recessive defects in livestock.

Reference : Highly effective SNP-based association mapping and management of recessive defects in li...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Genetics & genetic processes
	To cite this reference:	http://hdl.handle.net/2268/101985

Title :	Highly effective SNP-based association mapping and management of recessive defects in livestock.
Language :	English
Author, co-author :	Charlier, Carole [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
	Coppieters, Wouter [Université de Liège - ULg > Département de productions animales > Département de productions animales]
	Rollin, Frédéric [Université de Liège - ULg > Département clinique des animaux de production (DCP) > Médecine interne des équidés, des ruminants et des porcs]
	Desmecht, Daniel [Université de Liège - ULg > Département de morphologie et pathologie > Pathologie spéciale et autopsies]
	Agerholm, Jorgen S [> > > >]
	Cambisano, Nadine [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
	Carta, Eloisa [> > > >]
	Dardano, Sabrina [> > > >]
	Dive, Marc [> > > >]
	Fasquelle, Corinne [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine]
	Frennet, Jean-Claude [> > > >]*
	Hanset, Roger [> > > >]
	Hubin, Xavier [> > > >]
	Jorgensen, Claus [> > > >]
	Karim, Latifa [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire]
	Kent, Matthew [> > > >]
	Harvey, Kirsten [> > > >]
	Pearce, Brian R [> > > >]
	Simon, Patricia [Université de Liège - ULg > > Centre d'ingénierie des protéines]
	Tamma, Nico [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
	Nie, Haisheng [> > > >]
	Vandeputte, Sébastien [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Epidémiologie et analyse des risques appl. aux sc. vétér.]
	Lien, Sigbjorn [> > > >]
	Longeri, Maria [> > > >]
	Fredholm, Merete [> > > >]
	Harvey, Robert J [> > > >]
	Georges, Michel [ > > ]
Publication date :	2008
Journal title :	Nature Genetics
Publisher :	Nature Publishing Group
Volume :	40
Issue/season :	4
Pages :	449-54
Audience :	International
ISSN :	1061-4036
e-ISSN :	1546-1718
City :	New York
Country :	NY
Keywords :	[en] ATP-Binding Cassette Transporters/genetics ; Amino Acid Sequence ; Animals ; Animals, Domestic/genetics/growth & development ; Breeding ; Cattle ; Cattle Diseases/genetics ; Cells, Cultured ; Chromosome Mapping ; DNA Primers/chemistry ; Dystonia/congenital/genetics/veterinary ; Female ; Gene Expression Profiling ; Genes, Recessive/genetics ; Genetic Linkage ; Genetic Markers/genetics ; Glycine Plasma Membrane Transport Proteins/genetics ; Humans ; Male ; Molecular Sequence Data ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics ; Sequence Homology, Amino Acid
Abstract :	[en] The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of these: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practice, allowing marker assisted selection against the defects through avoidance of at-risk matings.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/101985
DOI :	10.1038/ng.96

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