Article (Scientific journals)
Highly effective SNP-based association mapping and management of recessive defects in livestock.
Charlier, Carole; Coppieters, Wouter; Rollin, Frédéric et al.
2008In Nature Genetics, 40 (4), p. 449-54
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Keywords :
ATP-Binding Cassette Transporters/genetics; Amino Acid Sequence; Animals; Animals, Domestic/genetics/growth & development; Breeding; Cattle; Cattle Diseases/genetics; Cells, Cultured; Chromosome Mapping; DNA Primers/chemistry; Dystonia/congenital/genetics/veterinary; Female; Gene Expression Profiling; Genes, Recessive/genetics; Genetic Linkage; Genetic Markers/genetics; Glycine Plasma Membrane Transport Proteins/genetics; Humans; Male; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Phenotype; Polymorphism, Single Nucleotide/genetics; Quantitative Trait Loci; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics; Sequence Homology, Amino Acid
Abstract :
[en] The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of these: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practice, allowing marker assisted selection against the defects through avoidance of at-risk matings.
Disciplines :
Genetics & genetic processes
Author, co-author :
Charlier, Carole  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Coppieters, Wouter ;  Université de Liège - ULiège > Département de productions animales > Département de productions animales
Rollin, Frédéric ;  Université de Liège - ULiège > Département clinique des animaux de production (DCP) > Médecine interne des équidés, des ruminants et des porcs
Desmecht, Daniel ;  Université de Liège - ULiège > Département de morphologie et pathologie > Pathologie spéciale et autopsies
Agerholm, Jorgen Steen
Cambisano, Nadine ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Carta, Eloisa
Dardano, Sabrina
Dive, Marc
Fasquelle, Corinne ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
Frennet, Jean*-Claude
Hanset, Roger
Hubin, Xavier
Jorgensen, Claus
Karim, Latifa ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Kent, Matthew
Harvey, Kirsten
Pearce, Brian R
Simon, Patricia ;  Université de Liège - ULiège > Centre d'ingénierie des protéines
Tamma, Nico ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Nie, Haisheng
Vandeputte, Sébastien ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Epidémiologie et analyse des risques appl. aux sc. vétér.
Lien, Sigbjorn
Longeri, Maria
Fredholm, Merete
Harvey, Robert J
More authors (17 more) Less
Language :
English
Title :
Highly effective SNP-based association mapping and management of recessive defects in livestock.
Publication date :
2008
Journal title :
Nature Genetics
ISSN :
1061-4036
eISSN :
1546-1718
Publisher :
Nature Publishing Group, New York, United States - New York
Volume :
40
Issue :
4
Pages :
449-54
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 November 2011

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