[en] A group of 100 totally or subtotally myeloperoxidase (MPO)-deficient individuals was compared to a reference population of 118 probands selected at random. Data for a protective effect of the deficiency against cardiovascular damage are presented. On the other hand, a significantly higher occurrence of severe infections and chronic inflammatory processes was noted among the deficient patients. An increased incidence of cancer among the MPO-deficient individuals was not demonstrated.
Disciplines :
Hematology
Author, co-author :
Kutter, D.
Devaquet, P.
Vanderstocken, G.
Paulus, Jean-Michel ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Marchal, V.
GOTHOT, André ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Language :
English
Title :
Consequences of total and subtotal myeloperoxidase deficiency: risk or benefit ?
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