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Article (Scientific journals)
Consequences of total and subtotal myeloperoxidase deficiency: risk or benefit ?
Kutter, D.; Devaquet, P.; Vanderstocken, G. et al.
2000In Acta Haematologica, 104 (1), p. 10-5
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Keywords :
Adolescent; Adult; Aged; Aged, 80 and over; Arthritis/enzymology/etiology; Cardiovascular Diseases/enzymology/prevention & control; Case-Control Studies; Chi-Square Distribution; Child; Child, Preschool; Chronic Disease; Female; Humans; Infection/enzymology/etiology; Male; Middle Aged; Myocardial Infarction/enzymology/prevention & control; Neoplasms/enzymology/etiology; Peroxidase/blood/deficiency/pharmacology; Risk Factors
Abstract :
[en] A group of 100 totally or subtotally myeloperoxidase (MPO)-deficient individuals was compared to a reference population of 118 probands selected at random. Data for a protective effect of the deficiency against cardiovascular damage are presented. On the other hand, a significantly higher occurrence of severe infections and chronic inflammatory processes was noted among the deficient patients. An increased incidence of cancer among the MPO-deficient individuals was not demonstrated.
Disciplines :
Hematology
Author, co-author :
Kutter, D.
Devaquet, P.
Vanderstocken, G.
Paulus, Jean-Michel ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Marchal, V.
GOTHOT, André ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Language :
English
Title :
Consequences of total and subtotal myeloperoxidase deficiency: risk or benefit ?
Publication date :
2000
Journal title :
Acta Haematologica
ISSN :
0001-5792
eISSN :
1421-9662
Publisher :
S. Karger
Volume :
104
Issue :
1
Pages :
10-5
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright 2000 S. Karger AG, Basel
Available on ORBi :
since 08 November 2011

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