Title : Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Language : English Author, co-author : Franke, Andre [> > > >] McGovern, Dermot P B [> > > >] Barrett, Jeffrey C [> > > >] Wang, Kai [> > > >] Radford-Smith, Graham L [> > > >] Ahmad, Tariq [> > > >] Lees, Charlie W [> > > >] Balschun, Tobias [> > > >] Lee, James [> > > >] Roberts, Rebecca [> > > >] Anderson, Carl A [> > > >] Bis, Joshua C [> > > >] Bumpstead, Suzanne [> > > >] Ellinghaus, David [> > > >] Festen, Eleonora M [> > > >] Georges, Michel [> > > >] Green, Todd [> > > >] Haritunians, Talin [> > > >] Jostins, Luke [> > > >] Latiano, Anna [> > > >] Mathew, Christopher G [> > > >] Montgomery, Grant W [> > > >] Prescott, Natalie J [> > > >] Raychaudhuri, Soumya [> > > >] Rotter, Jerome I [> > > >] Schumm, Philip [> > > >] Sharma, Yashoda [> > > >] Simms, Lisa A [> > > >] Taylor, Kent D [> > > >] Whiteman, David [> > > >] Wijmenga, Cisca [> > > >] Baldassano, Robert N [> > > >] Barclay, Murray [> > > >] Bayless, Theodore M [> > > >] Brand, Stephan [> > > >] Buning, Carsten [> > > >] Cohen, Albert [> > > >] Colombel, Jean*-Frederick [> > > >] Cottone, Mario [> > > >] Stronati, Laura [> > > >] Denson, Ted [Centre Hospitalier Universitaire de Liège - CHU > > Centre d'oncologie] DEVOS, Martine [> > > >] D'Inca, Renata [> > > >] Dubinsky, Marla [> > > >] Edwards, Cathryn [> > > >] Florin, Tim [> > > >] Franchimont, Denis [> > > >] Gearry, Richard [> > > >] Glas, Jurgen [> > > >] Van Gossum, Andre [> > > >] Guthery, Stephen L [> > > >] Halfvarson, Jonas [> > > >] Verspaget, Hein W [> > > >] Hugot, Jean*-Pierre [> > > >] Karban, Amir [> > > >] Laukens, Debby [> > > >] Lawrance, Ian [> > > >] Lemann, Marc [> > > >] Levine, Arie [Centre Hospitalier Universitaire de Liège - CHU > > Génétique] LIBIOULLE, Cécile [Université de Liège - ULg > Département des sciences cliniques > Hépato-gastroentérologie] Louis, Edouard [> > > >] Mowat, Craig [> > > >] Newman, William [> > > >] Panes, Julian [> > > >] Phillips, Anne [> > > >] Proctor, Deborah D [> > > >] Regueiro, Miguel [> > > >] Russell, Richard [> > > >] Rutgeerts, Paul [> > > >] Sanderson, Jeremy [> > > >] Sans, Miquel [> > > >] Seibold, Frank [> > > >] Steinhart, A Hillary [> > > >] Stokkers, Pieter C F [> > > >] Torkvist, Leif [> > > >] Kullak-Ublick, Gerd [> > > >] Wilson, David [> > > >] Walters, Thomas [> > > >] Targan, Stephan R [> > > >] Brant, Steven R [> > > >] Rioux, John D [> > > >] D'Amato, Mauro [> > > >] Weersma, Rinse K [> > > >] Kugathasan, Subra [> > > >] Griffiths, Anne M [> > > >] Mansfield, John C [> > > >] Vermeire, Severine [> > > >] Duerr, Richard H [> > > >] Silverberg, Mark S [> > > >] Satsangi, Jack [> > > >] Schreiber, Stefan [> > > >] Cho, Judy H [> > > >] Annese, Vito [> > > >] Hakonarson, Hakon [> > > >] Daly, Mark J [> > > >] Parkes, Miles [ > > ] Publication date : 2010 Journal title : Nature Genetics Publisher : Nature Publishing Group Volume : 42 Issue/season : 12 Pages : 1118-25 ISSN : 1061-4036 e-ISSN : 1546-1718 City : New York Country : NY Keywords : [en] Computational Biology ; Crohn Disease/etiology/genetics ; Genetic Linkage ; Genetic Loci/genetics ; Genetic Predisposition to Disease ; Genetic Variation ; Genome, Human/genetics ; Genome-Wide Association Study ; Humans ; Reproducibility of ResultsAbstract : [en] We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 x 10). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.Target : Researchers ; Professionals ; Students Permalink : http://hdl.handle.net/2268/101967 DOI : 10.1038/ng.717 
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