Reference : Characterization of the bovine pseudoautosomal boundary: Documenting the evolutionary hi...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/101961
Characterization of the bovine pseudoautosomal boundary: Documenting the evolutionary history of mammalian sex chromosomes.
English
Van Laere, Anne-Sophie mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Coppieters, Wouter mailto [Université de Liège - ULg > Département de productions animales > Département de productions animales]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
2008
Genome Research
Cold Spring Harbor Laboratory Press
18
12
1884-95
Yes (verified by ORBi)
International
1088-9051
1549-5469
Cold Spring Harbor
NY
[en] Animals ; Base Pairing ; Base Sequence ; Cattle ; Chromosome Mapping ; Chromosomes, Mammalian ; DNA/genetics/isolation & purification ; Evolution, Molecular ; Female ; Male ; Mammals/genetics ; Molecular Sequence Data ; Mutation ; Recombination, Genetic ; X Chromosome ; Y Chromosome
[en] Here, we report the sequence characterization of the bovine pseudoautosomal boundary (PAB) and its neighborhood. We demonstrate that it maps to the 5' end of the GPR143 gene, which has concomitantly lost upstream noncoding exons on the Y chromosome. We show that the bovine PAB was created approximately 20.7 million years ago by illegitimate intrachromatid recombination between inverted, ruminant-specific Bov-tA repeats. Accordingly, we demonstrate that cattle share their PAB with all other examined ruminants including sheep, but not with cetaceans or more distantly related mammals. We provide evidence that, since its creation, the ancestral ruminant PAB has been displaced by attrition, which occurs at variable rates in different species, and that it is capable of retreat by attrition erasure. We have estimated the ratio of male to female mutation rates in the Bovidae family as approximately 1.7, and we provide evidence that the mutation rate is higher in the recombining pseudoautosomal region than in the adjacent, nonrecombining gonosome-specific sequences.
Researchers ; Professionals
http://hdl.handle.net/2268/101961
also: http://hdl.handle.net/2268/101963
10.1101/gr.082487.108

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