Reference : A mutation creating a potential illegitimate microRNA target site in the myostatin gene ...
Scientific journals : Article
Life sciences : Genetics & genetic processes
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/101949
A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep.
English
Clop, Alex [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Marcq, Fabienne mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés]
Takeda, Haruko mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Pirottin, Dimitri mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Département de sciences fonctionnelles]
Tordoir, Xavier mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation]
Bibe, Bernard [> > > >]
Bouix, Jacques [> > > >]
Caiment, Florian [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Elsen, Jean-Michel [> > > >]
Eychenne, Francis [> > > >]
Larzul, Catherine [> > > >]
Laville, Elisabeth [> > > >]
Meish, Francoise [> > > >]
Milenkovic, Dragan [> > > >]
Tobin, James [> > > >]
Charlier, Carole mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
2006
Nature Genetics
Nature Publishing Group
38
7
813-8
Yes (verified by ORBi)
International
1061-4036
1546-1718
New York
NY
[en] Animals ; Binding Sites/genetics ; Chromosome Mapping ; Humans ; Hypertrophy ; Mice ; MicroRNAs/genetics ; Muscle, Skeletal/metabolism/pathology ; Mutation ; Myostatin ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Sheep/anatomy & histology/genetics ; Transforming Growth Factor beta/genetics
[en] Texel sheep are renowned for their exceptional meatiness. To identify the genes underlying this economically important feature, we performed a whole-genome scan in a Romanov x Texel F2 population. We mapped a quantitative trait locus with a major effect on muscle mass to chromosome 2 and subsequently fine-mapped it to a chromosome interval encompassing the myostatin (GDF8) gene. We herein demonstrate that the GDF8 allele of Texel sheep is characterized by a G to A transition in the 3' UTR that creates a target site for mir1 and mir206, microRNAs (miRNAs) that are highly expressed in skeletal muscle. This causes translational inhibition of the myostatin gene and hence contributes to the muscular hypertrophy of Texel sheep. Analysis of SNP databases for humans and mice demonstrates that mutations creating or destroying putative miRNA target sites are abundant and might be important effectors of phenotypic variation.
Researchers ; Professionals
http://hdl.handle.net/2268/101949
also: http://hdl.handle.net/2268/101953
10.1038/ng1810

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