Animals; Base Sequence; Molecular Sequence Data; Mosaicism/genetics; Muscular Diseases/genetics; Point Mutation; Sheep/abnormalities/genetics
Abstract :
[en] To identify the callipyge mutation, we have resequenced 184 kb spanning the DLK1-, GTL2-, PEG11-, and MEG8-imprinted domain and have identified an A-to-G transition in a highly conserved dodecamer motif between DLK1 and GTL2. This was the only difference found between the callipyge (CLPG) allele and a phylogenetically closely related wild-type allele. We report that this SNP is in perfect association with the callipyge genotype. The demonstration that Solid Gold-the alleged founder ram of the callipyge flock-is mosaic for this SNP virtually proves the causality of this SNP in the determinism of the callipyge phenotype.
Disciplines :
Veterinary medicine & animal health Genetics & genetic processes
Author, co-author :
Smit, Maria ✱
SEGERS, Karin ✱; Centre Hospitalier Universitaire de Liège - CHU > Génétique
Carrascosa, Laura Garcia
Shay, Tracy
Baraldi, Francesca
Gyapay, Gabor
Snowder, Gary
Georges, Michel ✱; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Cockett, Noelle ✱
Charlier, Carole ✱; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
✱ These authors have contributed equally to this work.
Language :
English
Title :
Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype.
Publication date :
2003
Journal title :
Genetics
ISSN :
0016-6731
eISSN :
1943-2631
Publisher :
Genetics Society of America, United States - Maryland
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