Article (Scientific journals)
Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype.
Smit, Maria; SEGERS, Karin; Carrascosa, Laura Garcia et al.
2003In Genetics, 163 (1), p. 453-6
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Keywords :
Animals; Base Sequence; Molecular Sequence Data; Mosaicism/genetics; Muscular Diseases/genetics; Point Mutation; Sheep/abnormalities/genetics
Abstract :
[en] To identify the callipyge mutation, we have resequenced 184 kb spanning the DLK1-, GTL2-, PEG11-, and MEG8-imprinted domain and have identified an A-to-G transition in a highly conserved dodecamer motif between DLK1 and GTL2. This was the only difference found between the callipyge (CLPG) allele and a phylogenetically closely related wild-type allele. We report that this SNP is in perfect association with the callipyge genotype. The demonstration that Solid Gold-the alleged founder ram of the callipyge flock-is mosaic for this SNP virtually proves the causality of this SNP in the determinism of the callipyge phenotype.
Disciplines :
Veterinary medicine & animal health
Genetics & genetic processes
Author, co-author :
Smit, Maria 
SEGERS, Karin  ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
Carrascosa, Laura Garcia
Shay, Tracy
Baraldi, Francesca
Gyapay, Gabor
Snowder, Gary
Georges, Michel   ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Cockett, Noelle 
Charlier, Carole   ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
 These authors have contributed equally to this work.
Language :
English
Title :
Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype.
Publication date :
2003
Journal title :
Genetics
ISSN :
0016-6731
eISSN :
1943-2631
Publisher :
Genetics Society of America, United States - Maryland
Volume :
163
Issue :
1
Pages :
453-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
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