ORBi: Farnir Frédéric - Simultaneous mining of linkage and linkage disequilibrium to fine map quantitative trait loci in outbred half-sib pedigrees: Revisiting the location of a quantitative trait locus with major effect on milk production on bovine chromosome 14

Reference : Simultaneous mining of linkage and linkage disequilibrium to fine map quantitative trait...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Veterinary medicine & animal health
	To cite this reference:	http://hdl.handle.net/2268/101932

Title :	Simultaneous mining of linkage and linkage disequilibrium to fine map quantitative trait loci in outbred half-sib pedigrees: Revisiting the location of a quantitative trait locus with major effect on milk production on bovine chromosome 14
Language :	English
Author, co-author :	Farnir, Frédéric [Université de Liège - ULg > Département de productions animales > Biostatistique, économie, sélection animale >]
	Grisart, B. [> > > >]
	Coppieters, Wouter [Université de Liège - ULg > Département de productions animales > Département de productions animales >]
	Riquet, J. [> > > >]
	Berzi, P. [> >]
	Cambisano, Nadine [Université de Liège - ULg > Département de productions animales > Génomique animale >]
	Karim, Latifa [Université de Liège - ULg > Département de productions animales > Génomique animale >]
	Mni, Myriam [Université de Liège - ULg > Département de productions animales > Génomique animale >]
	Moisio, S. [> > > >]
	Simon, P. [> >]
	Wagenaar, D. [> > > >]
	Vilkki, J. [> > > >]
	Georges, Michel [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Publication date :	2002
Journal title :	Genetics
Publisher :	Genetics
Volume :	161
Issue/season :	1
Pages :	275-287
Audience :	International
ISSN :	0016-6731
City :	Baltimore
Abstract :	[en] A maximum-likelihood QTL mapping method that simultaneously exploits linkage and linkage disequilibrium and that is applicable in outbred half-sib pedigrees is described. The method is applied to fine map a QTL with major effect on milk fat content in a 3-cM marker interval on proximal BTA14. This proximal location is confirmed by applying a haplotype-based association method referred to as recombinant ancestral haplotype analysis. The origin of the discrepancy between the QTL position derived in this work and that of a previous analysis is examined and shown to be due to the existence of distinct marker haplotypes associated with QTL alleles having large substitution effects.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/101932

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