Reference : Simultaneous mining of linkage and linkage disequilibrium to fine map quantitative tr...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/101932
Simultaneous mining of linkage and linkage disequilibrium to fine map quantitative trait loci in outbred half-sib pedigrees: Revisiting the location of a quantitative trait locus with major effect on milk production on bovine chromosome 14
English
Farnir, Frédéric mailto [Université de Liège - ULg > Département de productions animales > Biostatistique, économie, sélection animale >]
Grisart, B. [> > > >]
Coppieters, Wouter mailto [Université de Liège - ULg > Département de productions animales > Département de productions animales >]
Riquet, J. [> > > >]
Berzi, P. [> >]
Cambisano, Nadine mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Karim, Latifa mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Mni, Myriam mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Moisio, S. [> > > >]
Simon, P. [> >]
Wagenaar, D. [> > > >]
Vilkki, J. [> > > >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
2002
Genetics
Genetics
161
1
275-287
Yes (verified by ORBi)
International
0016-6731
Baltimore
[en] A maximum-likelihood QTL mapping method that simultaneously exploits linkage and linkage disequilibrium and that is applicable in outbred half-sib pedigrees is described. The method is applied to fine map a QTL with major effect on milk fat content in a 3-cM marker interval on proximal BTA14. This proximal location is confirmed by applying a haplotype-based association method referred to as recombinant ancestral haplotype analysis. The origin of the discrepancy between the QTL position derived in this work and that of a previous analysis is examined and shown to be due to the existence of distinct marker haplotypes associated with QTL alleles having large substitution effects.
Researchers ; Professionals
http://hdl.handle.net/2268/101932

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