Reference : Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the numb...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/101929
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
English
Anderson, Carl A [> > > >]
Boucher, Gabrielle [> > > >]
Lees, Charlie W [> > > >]
Franke, Andre [> > > >]
D'Amato, Mauro [> > > >]
Taylor, Kent D [> > > >]
Lee, James C [> > > >]
Goyette, Philippe [> > > >]
Imielinski, Marcin [> > > >]
Latiano, Anna [> > > >]
Lagace, Caroline [> > > >]
Scott, Regan [> > > >]
Amininejad, Leila [> > > >]
Bumpstead, Suzannah [> > > >]
Baidoo, Leonard [> > > >]
Baldassano, Robert N [> > > >]
Barclay, Murray [> > > >]
Bayless, Theodore M [> > > >]
Brand, Stephan [> > > >]
Buning, Carsten [> > > >]
Colombel, Jean*-Frederic [> > > >]
Denson, Lee A [> > > >]
DEVOS, Martine mailto [Centre Hospitalier Universitaire de Liège - CHU > > Centre d'oncologie]
Dubinsky, Marla [> > > >]
Edwards, Cathryn [> > > >]
Ellinghaus, David [> > > >]
Fehrmann, Rudolf S N [> > > >]
Floyd, James A B [> > > >]
Florin, Timothy [> > > >]
Franchimont, Denis [> > > >]
Franke, Lude [> > > >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Glas, Jurgen [> > > >]
Glazer, Nicole L [> > > >]
Guthery, Stephen L [> > > >]
Haritunians, Talin [> > > >]
Hayward, Nicholas K [> > > >]
Hugot, Jean*-Pierre [> > > >]
Jobin, Gilles [> > > >]
Laukens, Debby [> > > >]
Lawrance, Ian [> > > >]
Lemann, Marc [> > > >]
Levine, Arie [> > > >]
LIBIOULLE, Cécile mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique]
Louis, Edouard mailto [> > > >]
McGovern, Dermot P [> > > >]
Milla, Monica [> > > >]
Montgomery, Grant W [> > > >]
Morley, Katherine I [> > > >]
Mowat, Craig [> > > >]
Ng, Aylwin [> > > >]
Newman, William [> > > >]
Ophoff, Roel A [> > > >]
Papi, Laura [> > > >]
Palmieri, Orazio [> > > >]
Peyrin-Biroulet, Laurent [> > > >]
Panes, Julian [> > > >]
Phillips, Anne [> > > >]
Prescott, Natalie J [> > > >]
Proctor, Deborah D [> > > >]
Roberts, Rebecca [> > > >]
Russell, Richard [> > > >]
Rutgeerts, Paul [> > > >]
Sanderson, Jeremy [> > > >]
Sans, Miquel [> > > >]
Schumm, Philip [> > > >]
Seibold, Frank [> > > >]
Sharma, Yashoda [> > > >]
Simms, Lisa A [> > > >]
Seielstad, Mark [> > > >]
Steinhart, A Hillary [> > > >]
Targan, Stephan R [> > > >]
van den Berg, Leonard H [> > > >]
Vatn, Morten [> > > >]
Verspaget, Hein [> > > >]
Walters, Thomas [> > > >]
Wijmenga, Cisca [> > > >]
Wilson, David C [> > > >]
Westra, Harm*-Jan [> > > >]
Xavier, Ramnik J [> > > >]
Zhao, Zhen Z [> > > >]
Ponsioen, Cyriel Y [> > > >]
Andersen, Vibeke [> > > >]
Torkvist, Leif [> > > >]
Gazouli, Maria [> > > >]
Anagnou, Nicholas P [> > > >]
Karlsen, Tom H [> > > >]
Kupcinskas, Limas [> > > >]
Sventoraityte, Jurgita [> > > >]
Mansfield, John C [> > > >]
Kugathasan, Subra [> > > >]
Silverberg, Mark S [> > > >]
Halfvarson, Jonas [> > > >]
Rotter, Jerome I [> > > >]
Mathew, Christopher G [> > > >]
Griffiths, Anne M [> > > >]
Gearry, Richard [> > > >]
Ahmad, Tariq [> > > >]
Brant, Steven R [> > > >]
Chamaillard, Mathias [> > > >]
Satsangi, Jack [> > > >]
Cho, Judy H [> > > >]
Schreiber, Stefan [> > > >]
Daly, Mark J [> > > >]
Barrett, Jeffrey C [> > > >]
Parkes, Miles [> > > >]
Annese, Vito [> > > >]
Hakonarson, Hakon [> > > >]
Radford-Smith, Graham [> > > >]
Duerr, Richard H [> > > >]
Vermeire, Severine [> > > >]
Weersma, Rinse K [> > > >]
Rioux, John D [ > > ]
Feb-2011
Nature Genetics
Nature Publishing Group
43
3
246-52
Yes (verified by ORBi)
International
1061-4036
1546-1718
New York
NY
[en] Colitis, Ulcerative/genetics ; Crohn Disease/genetics ; Genome-Wide Association Study ; Humans ; Risk
[en] Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 x 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.
Researchers ; Professionals
http://hdl.handle.net/2268/101929
10.1038/ng.764

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