Article (Scientific journals)
Adult bone marrow: which stem cells for cellular therapy protocols in neurodegenerative disorders?
Wislet-Gendebien, Sabine; Laudet, Emerence; Neirinckx, Virginie et al.
2011In Journal of Biomedicine and Biotechnology
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Keywords :
Neural crest; stem cells; regenerative
Abstract :
[en] The generation of neuronal cells from stem cells obtained from adult bone marrow is of significant clinical interest in order to design new cell therapy protocols for several neurological disorders. The recent identification in adult bone marrow of stem cells derived from the neural crests (NCSC) might explain the neuronal phenotypic plasticity shown by bone marrow cells. However, little information is available about the nature of these cells compared to mesenchymal stem cells (MSC). In this manuscript, we will review all information available concerning NCSC from adult tissues and their possible use in regenerative medecine. Moreover, as multiple recent studies showed the beneficial effect of bone marrow stromal cells in neurodegenerative diseases, we will discuss which stem cells isolated from adult bone marrow should be more suitable for cell replacement therapy.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Wislet-Gendebien, Sabine  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Laudet, Emerence ;  Université de Liège - ULiège > GIGA - Neurosciences
Neirinckx, Virginie ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Rogister, Bernard  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Language :
English
Title :
Adult bone marrow: which stem cells for cellular therapy protocols in neurodegenerative disorders?
Publication date :
November 2011
Journal title :
Journal of Biomedicine and Biotechnology
ISSN :
1110-7243
eISSN :
1110-7251
Publisher :
Hindawi Publishing Corporation
Special issue title :
Toward Personalized Cell Therapies by Using Stem Cells
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 November 2011

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