Reference : Environmental factors affecting thyroid function of wild sea bass (Dicentrarchus labr...
Scientific journals : Article
Life sciences : Aquatic sciences & oceanology
http://hdl.handle.net/2268/100994
Environmental factors affecting thyroid function of wild sea bass (Dicentrarchus labrax) from European coasts
English
Schnitzler, Joseph mailto [Université de Liège - ULg > Département des sciences et gestion de l'environnement > Océanologie >]
Klaren, Peter [> >]
Bouquegneau, Jean-Marie mailto [Université de Liège - ULg > Département des sciences et gestion de l'environnement > Océanologie >]
Das, Krishna mailto [Université de Liège - ULg > Département des sciences et gestion de l'environnement > Océanologie >]
2012
Chemosphere
Elsevier Science
Yes (verified by ORBi)
International
0045-6535
Oxford
United Kingdom
[en] Dicentrarchus labrax ; Thyroid hormone metabolism ; Persistent organic pollutants
[en] Thyroid functional status of wild fish in relation with the contamination of their environment deserves further investigation. We here applied a multi-level approach of thyroid function assessment in 87 wild sea bass collected near several estuaries: namely the Scheldt, the Seine, the Loire, the Charente and the Gironde. Thyroxine (T4) and triiodothyronine (T3) concentrations in muscle were analyzed by radioimmunoassay. The activity of hepatic enzymes involved in extrathyroidal pathways of thyroid hormone metabolism, viz. deiodination, glucuronidation and sulfatation were analyzed. Last, follicle diameter and epithelial cell heights were measured. We observed changes that are predicted to lead to an increased conversion of T4–T3 and lowered thyroid hormone excretion. The changes in the metabolic pathways of thyroid hormones can be interpreted as a pathway to maintain thyroid hormone homeostasis. From all compounds tested, the higher chlorinated PCBs seemed to be the most implicated in this perturbation.
Centre Interfacultaire de Recherches en Océanologie - MARE ; Applied and Fundamental FISH Research Center - AFFISH-RC
Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA
Researchers ; Professionals ; Students ; General public ; Others
http://hdl.handle.net/2268/100994
10.1016/j.chemosphere.2011.11.039

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